Immunology Seminar Series

March 7th at 14:00 – 15:00 (Finland time)

Virtual event

Federica Sallusto, Institute of Microbiology, ETH Zurich: “Human T lymphocytes: differentiation, migration and immune regulation”

Host: Riitta Lahesmaa (rilahes@utu.fi )

Registration latest March 6th at https://link.webropolsurveys.com/S/3DB3A046C68F1559

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

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Federica Sallusto is professor of Medical Immunology at the ETH Zurich and USI and Group leader of the Cellular Immunology Laboratory at the IRB.  She is an expert in the field of human cellular immunology. Her research has focused on dendritic cell and T cell traffic, mechanisms of T cell differentiation and immunological memory. Among her contributions are the definition of “central memory” and “effector memory” T cells as memory subsets with distinct migratory capacity and effector function, the discovery of Th22 cells as a distinct subset of skin-homing T cells, the characterization of non-classic Th1 cells induced by bacteria and of two distinct types of Th17 cells with pro-inflammatory and regulatory properties. She also developed methods for the analysis of human naïve and memory T cell repertoires based on high throughput cellular screenings of expanded T cell libraries that has been instrumental to identify autoreactive T cells in patients with narcolepsy.

Federica Sallusto is currently Professor of Medical Immunology at the ETH Zurich and USI Lugano (joint professorship) and group leader of the Cellular Immunology Laboratory and Director of the Center of Medical Immunology at the Institute for Research in Biomedicine in Bellinzona. She is member of the German National Academy of Science Leopoldina, of EMBO and of the Henry Kunkel Society, international member of the U.S. National Academy of Sciences and honorary member of the Swiss Society for Allergology and Immunology. In 2022 she was honored with the title of Doctor honoris causa of the Faculty of Science and Medicine of the University of Fribourg. She is currently president of EFIS (European Federation of Immunological Societies).

Selected publications:

1. Becattini S, Latorre D, Mele F, Foglierini M, De Gregorio C, Cassotta A, Fernandez B, Kelderman S, Schumacher TN, Corti D, Lanzavecchia A, Sallusto F. Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines. Science 2015, 347:400-406.2.
2. Cassotta A, Paparoditis P, Geiger R, Mettu RR, Landry SJ, Donati A, Benevento M, Foglierini M, . Lewis DJM, Lanzavecchia A, Sallusto F. Deciphering and predicting CD4+ T cell immunodominance of Influenza virus hemagglutinin. J Exp Med 2020, 217:e20200206.
3. Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, Elarabi H, Croft CA, Doisne J-M, Zhang P, Weisshaar M, Jarrossay D, Latorre D, Shen Y, Han J, Gruber C, Markle J, Al Ali F, Rahman M, Khan T, Seeleuthner Y, Kerner G, Husquin LT, Maclsaac JL, Jeljeli M, Ailal F, Kobor MS, Oleaga-Quintas C, Roynard M, Bourgey M, El Baghdadi J, Boisson-Dupuis S, Puel A, Batteux F, Rozenberg F, Marr N, Pan-Hammarström Q, Bogunovic D, Quintana-Murci L, Carroll T, Ma CS, Abel L,  Bousfiha A, Di Santo JP, Glimcher LH, Gros P, Tangye S, Sallusto F, Bustamante J, Casanova JL. Human T-bet governs innate and innate-like adaptive IFN-g immunity against mycobacteria. Cell 2020, 183:1826-1847.