Pieta Mattila
Adjunct Professor
Institute of Biomedicine
University of Turku
Areas of expertise
Immunology, B cells, Antigen receptor signaling, Cell biology, Actin cytoskeleton, Plasma membrane, Advanced microscopy
Research
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, typically culminating at the reorganization of the actin cytoskeleton, plasma membranes and intracellular traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
Immunology, B cells, Antigen receptor signaling, Cell biology, Actin cytoskeleton, Plasma membrane, Advanced microscopy
Research
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, typically culminating at the reorganization of the actin cytoskeleton, plasma membranes and intracellular traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
