Publications

We in the InFLAMES Flagship expect to produce break-through knowledge on immunological principles and diseases, which will give rise to top-tier publications and international attention.

Selected Recent Publications

InFLAMES selected publicatons

Why Haven’t We Found an Effective Treatment for COVID-19?

Alexander James Spicer and Sirpa JalkanenP. Front. Immunol., 31 March 2021 | https://doi.org/10.3389/fimmu.2021.644850

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial

Sippola S, Haijanen J, Grönroos J, Rautio T, Nordström P, Rantanen T, Pinta T, Ilves I, Mattila A, Rintala J, Löyttyniemi E, Hurme S, Tammilehto V, Marttila H, Meriläinen S, Laukkarinen J, Sävelä E-L, Savolainen H, Sippola T, Aarnio M, Paajanen H, Salminen, P. JAMA. 2021. DOI: 10.1001/jama.2020.23525.

Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung

Jalkanen J, Pettilä V, Huttunen T, Hollmén M and Jalkanen S. Intensive Care Med. 2020. DOI: 10.1007/s00134-020-06086-3.

Fluctuation-Based Super-Resolution Traction Force Microscopy

Stubb A, Laine RF, Miihkinen M, Hamidi H, Guzmán C, Henriques R, Jacquemet G, Ivaska J. Nano Lett. 2020. DOI: 10.1021/acs.nanolett.9b04083.

Lymphatic endothelial cells of the lymph node

SJalkanen S, Salmi M. Nat. Rev. Immunol. 2020. DOI: 10.1038/s41577-020-0281-x.

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis.

Sucksdorff M, Matilainen M, Tuisku J, Polvinen E, Vuorimaa A, Rokka J, Nylund M, Rissanen E, Airas L. Brain. 2020. DOI: 10.1093/brain/awaa275.

First-in-Human Study of 68Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1.

Viitanen R, Moisio OA, Lankinen P, Li XG, Koivumäki M, Suilamo S, Tolvanen T, Taimen K, Mali M, Kohonen I, Koskivirta I, Oikonen V, Virtanen H, Santalahti K, Autio A, Saraste A, Pirilä L, Nuutila P, Knuuti J, Jalkanen S, Roivainen A. J Nucl Med. 2020. DOI: 10.2967/jnumed.120.250696.

Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes Journal of Clinical Investigation

Kähäri L, Fair-Mäkelä R, Auvinen K, Rantakari P, Jalkanen S, Ivaska J, Salmi M. J Clin Invest. 2019. DOI: 10.1172/JCI125740.

Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8(+) T-cell Response against Immunosuppressive Tumors Clinical Cancer Research

Viitala M, Virtakoivu R, Tadayon S, Rannikko J, Jalkanen S, Hollmen M. Clin Canc Res. 2019. DOI: 10.1158/1078-0432.CCR-18-3016.

Clever-1 contributes to lymphocyte entry into the spleen via the red pulp Science Immunology

Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmen M, Jalkanen S. Sci Immunol. 2019. DOI: 10.1126/sciimmunol.aat0297.

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K,Lahesmaa R, Teichmann SA. Cell. 2019. DOI: 10.1016/j.cell.2018.11.044.

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.

Kallionpää H, Somani J, Tuomela S, Ullah U, de Albuquerque R, Lönnberg T, Komsi E, Siljander H, Honkanen J, Härkönen T, Peet A, Tillmann V, Chandra V, Anagandula MK, Frisk G, Otonkoski T, Rasool O, Lund R, Lähdesmäki H, Knip M, Lahesmaa R. Diabetes. 2019. DOI: 10.2337/db19-0287.

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils Immunity

Takeda A, Hollmen M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S. Immunity. 2019. DOI: 10.1016/j.immuni.2019.06.027.

Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice Gut

Hänninen A, Toivonen R, Pöysti S, Belzer C, Plovier H, Ouwerkerk JP, Emani R, Cani PD, De Vos WM. Gut. 2018. DOI: 10.1136/gutjnl-2017-314508.

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

Salminen P, Tuominen R, Paajanen H, Rautio T, Nordstrom P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Virtanen J, Jartti A, Gronroos JM. JAMA. 2018. DOI: 10.1001/jama.2018.13201

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

Kauko O, O’Connor CM, Kulesskiy E, Sangodkar J, Aakula A, Izadmehr S, Yetukuri L, Yadav B, Padzik A, Laajala TM, Haapaniemi P, Momeny M, Varila T, Ohlmeyer M, Aittokallio T, Wennerberg K, Narla G, Westermarck J. Sci Transl Med. 2018. DOI: 10.1126/scitranslmed.aaq1093.

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions.

van Engeland NCA, Pollet AMAO, den Toonder JMJ, Bouten CVC, Stassen OMJA, Sahlgren CM. Lab Chip. 2018. DOI: 10.1039/c8lc00286j.