Immunology Seminar

November 14th, 2023, at 14-15 Finland time
Virtual event

Liv Eidsmo, MD, PhD, LEO Foundation Skin Immunology Research Center, Copenhagen, Denmark: Maintenance and renewal of skin resident T cells in inflammatory skin diseases

Host: Riitta Lahesmaa ( rilahes@utu.fi )

Registration latest November 13th at: https://link.webropolsurveys.com/S/584ABB98FFE02F8F

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

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Liv Eidsmo is a board certified dermatologist, a Professor of Translational Skin Immunology and the Executive Director of the LEO Foundation Skin Immunology Research Center at the University of Copenhagen. Eidsmo graduated from Karolinska Institutet, Sweden. Following a postdoc in Frank Carbone’s laboratory at Melbourne University in Australia, her first laboratory was established at the Center for Molecular Medicine (CMM) at Karolinska Institutet in parallel to clinical training in dermatology at Karolinska University Hospital. The current laboratory at University of Copenhagen focuses on how T cells residing in the skin drive local recurrence of diseases such as psoriasis and vitiligo.  https://sic.ku.dk/research/translational-skin-immunology/

Selected publications:

Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. Zitti B, Hoffer E, Zheng W, Pandey RV, Schlums H, Perinetti Casoni G, Fusi I, Nguyen L, Kärner J, Kokkinou E, Carrasco A, Gahm J, Ehrström M, Happaniemi S, Keita ÅV, Hedin CRH, Mjösberg J, Eidsmo L, Bryceson YT. Immunity. 2023 Jun 13;56(6):1285-1302.e7. doi: 10.1016/j.immuni.2023.05.003.

Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation. Zwijnenburg AJ, Pokharel J, Varnaitė R, Zheng W, Hoffer E, Shryki I, Comet NR, Ehrström M, Gredmark-Russ S, Eidsmo L, Gerlach C. Immunity. 2023 Aug 8;56(8):1955-1974.e10. doi: 10.1016/j.immuni.2023.06.025.

T cells in resolved allergic contact dermatitis steer tissue inflammation and MMP-12-driven tissue modulation. Gallais Sérézal I, Tajpara P, Schonfeldt T, Ignatov B, Sortebech D, Hoffer E, Zhang T, Rooijackers E, Ehrström M, Nylén S, Matura M, Melican K, Eidsmo L. Allergy. 2022 Dec;77(12):3680-3683. doi: 10.1111/all.15484.

Long-term Outcomes and Prognosis in New-Onset Psoriasis. Svedbom A, Mallbris L, Larsson P, Nikamo P, Wolk K, Kjellman P, Sonkoly E, Eidsmo L, Lindqvist U, Ståhle M. JAMA Dermatol. 2021 Apr 14;157(6):1-8. doi: 10.1001/jamadermatol.2021.0734.

A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis. Gallais Sérézal I, Hoffer E, Ignatov B, Martini E, Zitti B, Ehrström M, Eidsmo L. J Allergy Clin Immunol. 2019 Apr;143(4):1444-1454. doi: 10.1016/j.jaci.2018.08.048.