December 12^th at 12:00
Onsite event
in Presidentti auditorium, BioCity
Autumn 2024 program

Prof. Torben Heick Jensen, Aarhus Universitet, Denmark
Nuclear sorting of RNA
Host: Matti Turtola (matti.turtola@utu.fi)

Coffee and sandwich at 11:45, first come first served!

Six PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Jensen after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

The discovery that most of the human genome is transcriptionally active poses a fascinating question: how do cells manage this vast array of transcripts? Prof. Jensen’s research focuses on uncovering the fundamental mechanisms of transcriptome regulation. His work spans diverse aspects of RNA metabolism, including transcription, RNA decay, long non-coding RNAs, snoRNAs, RNA modifications, transposable elements, molecular recognition, and RNA-binding proteins. Additionally, the Jensen lab develops and applies cutting-edge methodologies to study transcriptome dynamics, going far beyond standard RNA-Seq analyses.

Selected publications

Imamura, K., Garland, W., Schmid, M., Jakobsen, L., Sato, K., Rouvière, J. O., Jakobsen, K. P., Burlacu, E., Lopez, M. L., Lykke-Andersen, S., Andersen, J. S. & Jensen, T. H. (2024). A functional connection between the Microprocessor and a variant NEXT complex. Molecular Cell, 84(21), 4158-4174.e6.

Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Molska EŠ, Wu G, Schmid M, Bugai A, Jakobsen L, Žumer K, Cramer P, Andersen JS, Conti E, Jensen TH. (2023) ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts. Mol Cell. 83, 2240-2257.e6.

Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH. (2022) Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Mol Cell. 82, 1691-1707.e8.

Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH. (2021) Integrator is a genome-wide attenuator of non-productive transcription. Mol Cell. 81,514-529.e6.

Lykke-Andersen, S., Rouvière, J. O., Schmid, M., Gockert, M. & Jensen, T. H. (2024). Protocol for generating customizable and reproducible plots of sequencing coverage data using the seqNdisplayR package. STAR Protocols, 5(2), Article 102960.

General information

• You can download and save all the autumn 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyMOL Molecular Graphics System, Version 2.5 Schrödinger, LLC.