When: December 11, 2025 at 10:00–11:00
Where: Arje Scheinin lecture room, Dentalia
Speaker: Professor Marco Demaria, University of Groningen, The Netherlands
Host: Senior Research Fellow Gennadi Egutkin

About Professor Demaria:

Dr Demaria is an associate professor in Cellular Ageing and his research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. His laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs.

About Demaria lab:

“We investigate how cellular senescence and other cell fates alter the tissue microenvironment and influence the aging process, the capacity to recover from transient and chronic injury, and the onset and progression of age-related pathology. We aim to understand basic molecular and cellular mechanisms, and target such mechanisms to create therapies that enhance healthy longevity. Our multidisciplinary research spans basic, translational, and clinical approaches.”

Selected publications

The senescence-associated secretory phenotype and its physiological and pathological implications. Wang B, Han J, Elisseeff JH, Demaria M. Nat Rev Mol Cell Biol. 2024 Dec;25(12):958-978. doi: 10.1038/s41580-024-00727-x. Epub 2024 Apr 23. PMID: 38654098

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg SM, Faller WJ, Ridky TW, Demaria M. Nat Commun. 2022 Dec 23;13(1):7923. doi: 10.1038/s41467-022-35657-9. PMID: 36564381

Senescence and cancer – role and therapeutic opportunities. Schmitt CA, Wang B, Demaria M. Nat Rev Clin Oncol. 2022 Oct;19(10):619-636. doi: 10.1038/s41571-022-00668-4. Epub 2022 Aug 31. PMID: 36045302

The senescence-associated secretory phenotype and its physiological and pathological implications. Wang B, Han J, Elisseeff JH, Demaria M. Nat Rev Mol Cell Biol. 2024 Dec;25(12):958-978. doi: 10.1038/s41580-024-00727-x. Epub 2024 Apr 23. PMID: 38654098

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg SM, Faller WJ, Ridky TW, Demaria M. Nat Commun. 2022 Dec 23;13(1):7923. doi: 10.1038/s41467-022-35657-9. PMID: 36564381

Senescence and cancer – role and therapeutic opportunities. Schmitt CA, Wang B, Demaria M. Nat Rev Clin Oncol. 2022 Oct;19(10):619-636. doi: 10.1038/s41571-022-00668-4. Epub 2022 Aug 31. PMID: 36045302