Matti Poutanen
Professor
Institute of Biomedicine
University of Turku
Areas of expertise
Genetically modified mice, sex steroids, endometriosis and hormonal cancer
Research
Our research group has been internationally in a key position in providing evidence for the concept where the ligand concentration available for steroid hormone receptor binding is markedly regulated by the target tissue metabolism, termed intracrine steroid hormone action. The concept has proven to be essential for the growth and progression of both prostate and breast cancer. We, furthermore, have shown this concept to be valid also in premenopausal women, eg. in the endometriosis, and other medically relevant implications are expected to rise in the near future.
Genetically modified mice, sex steroids, endometriosis and hormonal cancer
Research
Our research group has been internationally in a key position in providing evidence for the concept where the ligand concentration available for steroid hormone receptor binding is markedly regulated by the target tissue metabolism, termed intracrine steroid hormone action. The concept has proven to be essential for the growth and progression of both prostate and breast cancer. We, furthermore, have shown this concept to be valid also in premenopausal women, eg. in the endometriosis, and other medically relevant implications are expected to rise in the near future.
