Immunology Seminar

October 10th, 2023, at 14-15 Finland time

Virtual event

Vivianne Malmström, Karolinska Institutet: Lymphocyte repertoires and antigen specificities in rheumatoid arthritis

Host: Riitta Lahesmaa ( rilahes@utu.fi )

Registration latest October 9^th at: https://link.webropolsurveys.com/S/95418E5D0D3C03A5

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

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Professor Vivianne Malmström leads research group at Karolinska Institutet at the Department of Medicine, Division of Rheumatology. The Malmström research group focuses on studying the malfunctioning adaptive immune system in patients with rheumatic disease. The prototype disease under investigation is rheumatoid arthritis, but we also study SLE, ANCA-vasculitis and myositis.

They strive to understand both the magnitude and ‘flavour’ of the underlying autoimmunity in the different disease settings. Their approaches span from cellular immunology and structural biochemistry to single cell transcriptomics.

https://ki.se/en/meds/research-group-vivianne-malmstrom

Recent papers:

Joshua V, Loberg-Haarhaus M*, Hensvold A*, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Grönwall C, Klareskog L, Rethi B, Catrina AI and Malmström V. Rheumatoid arthritis specific autoimmunity in the lung before, and at, onset of disease. 2023 Arthritis Rheumatol PMID: 37192126

Turcinov S, af Klint E, van Schoubroeck B, Kouwenhovenn A, Sohel MM, Chemin K, Wils H, van Hove C, de Bondt A, Keustermans K, van Houdt J, Reumers J, Felix N, Rao NL, Peters P, Steveneart F, Klareskog L, McKinnon M, Baker D, Suri A, Malmström V. Diversity and clonality of T cell receptor repertoire and antigen specificities in small joints of early RA. 2023 Arthritis Rheum 75:673-684 PMID: 36409582

Hardt U, Carlberg K, af Klint E, Sahlström P, Larsson L, van Vollenhoven A, Hernandez Machado S, Israelsson L, Amara K, Chemin K, Korotkova M, Karlsson-Hedestam G, Catrina AI, Teichmann SA, Ståhl P and Malmström V. Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis 2022 Sci Rep 12:11876 PMID: 35831338

Argyriou A, Wadsworth MH, Lendvai A, Christensen SM, Hensvold AH, Gerstner C, Kravarik K, Winkler A, Malmström V and Chemin K. Single cell sequencing reveals expanded cytotoxic CD4+ T cells and two states of peripheral helper T cells in synovial fluid of ACPA+ RA patients. 2022 Nat Comm 13:4046 PMID: 35831277

Sharma RK, Boddul SV, Yoosuf N, Turcinov S, Dubnovitsky A, Kozhukh G, Wermeling F, Kwok WW, Klareskog L and Malmström V. Biased TCR gene usage in citrullinated Tenascin C specific T-cells in RA: Implications for future T-cell directed therapies. 2021 Sci Rep 11:24512 PMID: 34972837

Malmström V, Catrina AI, and Klareskog L. The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. 2017 Nat Rev Immunol 17:60-75. PMID: 27916980