Guest seminar: Dr. Achim Doerner
Scientific Director for Antibody Discovery and Protein Engineering, Merck Healthcare

Title: Therapeutic Antibody Hit Discovery
When: Thu December 12th, 2024 at 13:00–14:00
Where: Ministeri lecture room, BioCity, Tykistökatu 6
Host: Urpo Lamminmäki, University of Turku, Department of Life Technologies

About Dr. Achim Doerner:

A biochemist by training, Achim has been designing and progressing bispecific antibodies and ADCs through preclinical development for over a decade. Complementary interests are protein engineering and technology development for plate-based bispecific antibody screening and mammalian libraries for microfluidic functional screens.

Selected publications:

Slavny, P; Hegde, M; Doerner, A; Parthiban, K; McCafferty, J; Zielonka, S; Hoet, R Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects. Front. Immunol., 2024, 24, 1469329, https://doi.org/10.3389/fimmu.2024.1469329

Evers, A.; Krah, S.; Demir, D.; Gaa, R.; Elter, D.; Schroeter, C.; Zielonka, S.; Rasche, N.; Dotterweich, J.; Knuehl, C.; Doerner, A. Engineering Hydrophobicity and Manufacturability for Optimized Biparatopic Antibody-Drug Conjugates Targeting c-MET. MAbs 2024, 16, 2302386, doi:10.1080/19420862.2024.2302386.

Barron, N.; Dickgiesser, S.; Fleischer, M.; Bachmann, A.-N.; Klewinghaus, D.; Hannewald, J.; Ciesielski, E.; Kusters, I.; Hammann, T.; Doerner, A. A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates. Int. J. Mol. Sci. 2024, 25, doi:10.3390/ijms25042097.

Lipinski, B.; Unmuth, L.; Arras, P.; Becker, S.; Bauer, C.; Toleikis, L.; Krah, S.; Doerner, A.; Yanakieva, D.; Boje, A.S.; et al. Generation and Engineering of Potent Single Domain Antibody-Based Bispecific IL-18 Mimetics Resistant to IL-18BP Decoy Receptor Inhibition. MAbs 2023, 15, 2236265, doi:10.1080/19420862.2023.2236265.

Gaa, R.; Mayer, H.M.; Noack, D.; Doerner, A. Efficient Microfluidic Downstream Processes for Rapid Antibody Hit Confirmation. Methods Mol. Biol. 2023, 2681, 327–341, doi:10.1007/978-1-0716-3279-6_18.