23rd October at 12:00
Onsite event
in Presidentti auditorium, BioCity
Autumn 2025 program

Prof. Francesca Bottanelli, Freie Universität Berlin, Germany
Unravelling the inner secrets of cells with live-cell super-resolution microscopy

Host: Paulina Moreno Layseca (paulina.morenolayseca@utu.fi)

Coffee and sandwich served at 11:45, first come first serve!

Six PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Bottanelli after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

Bottanelli laboratory integrates endogenous tagging with live-cell super-resolution STED microscopy to illuminate dynamic processes occurring at the nanoscale and in the unperturbed physiological environment of the cell. They have generated a comprehensive library of proteins involved in membrane homeostasis. The ability to explore endogenous cellular dynamics is revealing novel and unexplored sorting mechanisms. Bottanelli lab has provided functional characterization of a novel sorting compartment that was named ARF1 compartment. ARF1 compartments orchestrate clathrin-dependent post-Golgi trafficking via maturing into recycling endosomes. Bottanelli lab also studies the function of microvilli as a signaling organelle and investigate how signalling molecules dynamically re-organize on membrane protrusions during chimeric antigenic receptor (CAR)–mediated activation.

Selected publications

Stockhammer A, Adarska P, Natalia V, Heuhsen, …, Haucke V. & Bottanelli F. (2024) ARF1 compartments direct cargo flow via maturation into recycling endosomes. Nat Cell Biol.

Maib H, Adarska P, Hunton R, Vines J, Strutt D, Bottanelli F & Murray D. H. (2024) Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides. J Cell Biol. 223 (6): e202310095

Rentsch J, Bandstra S, Sezen B, Sigrist PS, Bottanelli F, Schmerl B, Shoichet S, Noé F, Sadeghi M and Ewers H (2024) Sub-membrane actin rings compartmentalize the plasma membrane. J Cell Biol. 1;223(4):e202310138

Wong-Dilworth L, Rodilla-Ramirez C, Fox E, Restel S, Stockhammer A, Adarska P and Bottanelli F (2023) STED imaging of endogenously tagged ARF GTPases reveals their distinct nanoscale localizations. J Cell Biol, 222 (7): e202205107

General information

• You can download and save all the autumn 2025 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2025 image credits to Kari Kaunisto: Sahlberg family collections, Biodiversity unit, University of Turku