Frontiers of Science: Assoc. Prof. Sirio Dupont

When

March 7, 2024    
12:00 pm - 1:00 pm

Event Type

March 7th at 12:00
On-site event
Presidentti auditorium, BioCity
Spring 2024 program

Assoc. Prof. Sirio Dupont, University of Padova, Italy
Mitochondrial fission coordinates the transcriptional and metabolic response to forces
Host: Johanna Ivaska (johanna.ivaska@utu.fi)

Coffee and sandwich at 11:45, first come first served!

 

Six PhD researchers and early-career postdocs are welcome to have a lunch in restaurant Mauno and discuss with Assoc. Prof. Dupont after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

 

Dupont lab is interested in understanding how the mechanical properties of the extracellular matrix (ECM) regulate signaling pathways, gene transcription and other cellular processes, and how this is relevant for cell behavior, tissue homeostasis and disease. Their goal is to identify novel general principles in vitro, and to push their validation in vivo with the development of new animal models to study mechano-signaling in tissues. Dupont lab uses a multidisciplinary approach that includes custom-built compliant cell culture substrata, ECM micropatterning, cell micromanipulations, optical microscopy, molecular and cell biology techniques, transcriptional and bioinformatic analyses, proteomics, metabolomics, CRISPR/Cas9 modified cell lines, and genetically-modified mice, also thanks to multiple collaborations with colleagues in Italy and abroad. Dupont lab has identified YAP/TAZ transcriptional coactivators as readers of ECM mechanical cues and mediators of their effects on cancer cell proliferation and mesenchymal stem cell differentiation, and are now developing genetic tools to study the relevance of F-actin remodeling as regulator of YAP/TAZ activity in vivo. Moreover, they got recently interested in understanding how mechanical cues, YAP/TAZ and metabolism are reciprocally regulated.

 

Selected publications

Dupont S, Wickström SA. 2022. Mechanical regulation of chromatin and transcription. Nat Rev Genet. 2022 Oct;23(10):624-643. doi: 10.1038/s41576-022-00493-6

Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S. 2022. Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb;24(2):168-180. doi: 10.1038/s41556-022-00843-wPMID: 35165418

Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S. 2019. Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP. Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5

 

General information

  • You can download and save all the spring 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
  • Registration is not needed, participation list is circulated in the audience
  • If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
  • Please note that any audio or video recording of the seminars is strictly forbidden.
  • Spring 2024 FoS image credits to Jenny Pessa: Transformed human breast epithelial HS578T cells (flattened), labelled with commercial fluorescent antibodies. Image acquired on 3i CSU-W1 Spinning disk with 40x objective.