September 22^nd at 12:00
on-site event
Presidentti auditorium, BioCity

Prof. Gwendalyn Randolph, Washington University School of Medicine St. Louis, US
Let it go! (or not): regulation of the dissemination of cells and molecules from tissues during inflammation
host: Sirpa Jalkanen (sirpa.jalkanen@utu.fi)

Coffee and sandwich served at 11:45

Gwendalyn J. Randolph will be Sina Tadayon’s opponent 21.9.2022 and she will give a seminar 22.9.2022 at noon. Thereafter, she is available for a student lunch and for individual discussions. Please, register for the student lunch and reserve the time for discussion from Kaisa Hakkila (kaihak@utu.fi)

Gwendalyn J. Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis, Missouri, where she is currently co-director of the Immunology Graduate Program. During her postdoctoral work, Randolph characterized monocyte differentiation to dendritic cells and macrophages and made advances in our understanding of dendritic cell trafficking and the fate of monocytes recruited to sites of inflammation. Her lab has contributed to the Immunological Genome Project by characterizing macrophage gene expression. Her work now focuses on the immunological mechanisms driving atherosclerosis and inflammatory bowel disease (IBD) by exploring lymphatic function and lipoprotein trafficking.

Selected publications

M Uzzan, JC Martin, L Mesin, AE Livanos, T Castro-Dopico, R Huang, …, Randolph GJ, Kenigsberg E, Colombel JF, Mehandru S. 2022. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nature medicine 28 (4), 766-779

JM Amrute, AM Perry, G Anand, C Cruchaga, KG Hock, CW Farnsworth, Randolph GJ, Lavine KJ, Steed AL. 2022. Cell specific peripheral immune responses predict survival in critical COVID-19 patients.  Nature communications 13 (1), 1-11

RS Czepielewski, EC Erlich, EJ Onufer, S Young, BT Saunders, YH Han, …, Randolph GJ. 2021. Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. Immunity 54 (12), 2795-2811. e9

YH Han, EJ Onufer, LH Huang, RW Sprung, WS Davidson, …, Randolph GJ. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science 373 (6553), eabe6729

V Cifarelli, S Appak-Baskoy, VS Peche, A Kluzak, T Shew, R Narendran, …, Randolph GJ, Augustin HG, Abumrad NA. 2021. Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells. Nature communications 12 (1), 1-15