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UID:234@inflames.utu.fi
DTSTART;TZID=Europe/Helsinki:20230426T000000
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DTSTAMP:20230217T132516Z
URL:https://inflames.utu.fi/events/initialise-minisymposium/
SUMMARY:INITIALISE Minisymposium
DESCRIPTION:Minisymposium organised by EU funded INITIALISE project. More d
 etails and speaker list coming later.\n\n&nbsp\;\n\nShort summary of INITI
 ALISE\nINITIALISE is an EU funded project that aims to elucidate how expos
 ures and genome impact gut microbiome\, host immune system and metabolism\
 , and how the interplay of these factors impact life-course health. INITIA
 LISE aims to define the role of the maturation of the immune system as a m
 ediator between exposures and life-course health.\n\nThe development of th
 e human immune system in early life\, including in utero\, impacts the ris
 ks of several diseases later in life\, particularly immune-mediated diseas
 es such as allergies\, asthma\, and autoimmunity. Yet\, the mechanisms of 
 early life immune imprinting have been poorly understood in humans due to 
 the difficulty in obtaining samples and the challenges of deriving the mos
 t important data from small sample volumes available. Furthermore\, these 
 studies are complicated by the many simultaneous exposures with potential 
 impact on developing immune cells\, colonizing microbes\, and immune-micro
 be mutualism. To better understand such interactions\, a combinations of l
 arge population studies with longitudinal data and long-term follow-up and
  more detailed studies in smaller sets of children will be needed.\nThis p
 roject will use a combination of discovery-driven multi-omics and mechanis
 tic/functional studies. Our discovery-driven multi-omics studies will be c
 onducted in longitudinal settings in participating prospective birth cohor
 ts\, where the objective will be to link early-life exposures (including c
 hemical exposures)\, (epi)genome\, metabolome\, proteome\, immunome (deep 
 immune phenotyping using mass cytometry)\, transcriptome\, and gut microbi
 ome with specific adverse outcomes later in life\, across three domains 
 – immune (immune-mediated diseases)\, metabolic (obesity)\, and neurocog
 nitive.\nThis will enable us to understand the environmental factors shapi
 ng human immune systems early in life\, their mechanisms of action\, and i
 mpact on life-course health.
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