BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:146@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20220203T110000 DTEND;TZID=Europe/Helsinki:20220203T120000 DTSTAMP:20230120T083246Z URL:https://inflames.utu.fi/events/inflames-visitor-associate-professor-ma ria-yuseff-guest-seminar/ SUMMARY:InFLAMES Visitor Guest Seminar: Associate Professor María Yuseff DESCRIPTION:A Special seminar by the EMBO Global Investigator\, Associate P rof María Isabel Yuseff\, the Pontificia Universidad Catolica de Chile\, on next Tuesday 1.2. at 13:00 in Lauren-2 lecture hall.\n\n \;\n\nThe title of her talk is:\n\nCoupling Cytoskeleton Dynamics to Polarized lysos ome Trafficking: Impact on B cell Responses.\n\n \;\n\nDr Yuseff’s r esearch in immune cell biology focuses on addressing two fundamental quest ions: 1. How B lymphocytes orchestrate cytoskeleton and organelle dynamics (lysosome/ER) to promote their antigen processing and presenting function s\, and 2. How are these processes are tuned in inflammation responses and in pathologies such as autoimmunity. By combining cell biological approac hes and immunological assays the research group recently revealed two mech anisms that regulate membrane trafficking at the B cell synapse\, enabling them to become competent as antigen presenting cells. The first one invol ves the exocyst complex\, which is assembled upon B cell activation and re gulates local exocytosis of lysosomes at the synaptic membrane. The second one involves local protein degradation\, controlled by the proteasome\, w hich regulates actin remodeling\, membrane trafficking\, and cell spreadin g upon antigen recognition.\n\n \;\n\nDr Yuseff is visiting the Univer sity of Turku for three weeks\, until 18.2. You are welcome to also meet w ith her in person. In such case\, please contact Academy Research Fellow P ieta Mattila (pieta.mattila@utu.fi).\n\n \;\n\nSome of the latest publ ications by Dr Yuseff are listed below:\n\n Ulloa\, R.\, Corrales\, O.\, Cabrera\, F.\, Jara-Wilde\, J.\, Saez\, JJ.\, Rivas\, C.\, Lagos\, J.\, Ha ̈rtel\, S.\, Quiroga\, C.\, Yuseff MI*\, Jheimmy Diaz Muñoz*. B cells a dapt their nuclear morphology to organize the immune synapse and facilitat e antigen extraction.\n Cabrera-Reyes F\, Parra-Ruiz C\, Yuseff MI*\, Zan lungo S*. “Alterations in Lysosome Homeostasis in Lipid-Related Disorder s: Impact on Metabolic Tissues and Immune Cells” Front Cell Dev Biol. 20 21 Dec 10\;9:790568. doi: 10.3389/fcell.2021.790568.\n Ibañez-Vega\, J. \, Del Valle\, F.\, Sáez\, JJ.\, Guzmán\, F.\, Diaz\, J.\, Soza\, A.\, Yuseff\, MI*. “Ecm29-Dependent Proteasome Localization Regulates Cytosk eleton Remodeling at the Immune Synapse” Front Cell Dev Biol. 2021 May 1 3\,9:650817. doi: 10.3389/fcell.2021.650817.\n Sáez\, JJ.\, Diaz\, J.\, Ibañez\, J.\, Bozo\, JP.\, Cabrera\, R.\, Alamo\, M.\, Gobert\, FX.\, O bino\, D\, Bono\, MR.\, Lennon-Duménil\, AM.\, Yeaman\, C and Yuseff. MI . “The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells” J Cell Biol. 2019 Jun 13. pii: jcb.201811131 \n Ibañez\, J.\, Del Valle-Batalla\, F.\, Sáez\, JJ.\, Soza\, A. and Yuseff MI. “Proteasome dependent actin remodeling facilitates antigen ex traction at the immune synapse of B cells”. Front Immunol. 2019 Feb 19\; 10:225.\n Obino D\, Fetler L\, Soza A\, Malbec O\, Saez JJ\, Labarca M\, Oyanadel C\, Del Valle Batalla F\, Goles N\, Chikina A\, Lankar D\, Segovi a-Miranda F\, Garcia C\, Léger T\, Gonzalez A\, Espéli M\, Lennon-Dume ́nil AM\, Yuseff MI. "Galectin-8 favors the presentation of surface-tethe red antigens by stabilizing the B cell immune synapse". Cell Rep. 2018 Dec 11\;25(11):3110-3122.e6.\n Obino D\, Diaz J\, Sáez JJ\, Ibañez-Vega J\, Sáez PJ\, Alamo M\, Lankar D\, Yuseff MI. “Vamp-7-dependent secret ion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes”.Mol Biol Cell. 2017.Apr 1\;28(7):890-897.\n END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20211031T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR