BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.2.3.1//EN
TZID:Europe/Helsinki
X-WR-TIMEZONE:Europe/Helsinki
BEGIN:VEVENT
UID:410@inflames.utu.fi
DTSTART;TZID=Europe/Helsinki:20250528T110000
DTEND;TZID=Europe/Helsinki:20250528T120000
DTSTAMP:20250509T122902Z
URL:https://inflames.utu.fi/events/inflames-guest-seminar-mikhail-a-nikifo
 rov/
SUMMARY:InFLAMES guest seminar: Mikhail A. Nikiforov
DESCRIPTION:When: May 28\, 2025 at 11:00–12:00\nWhere: Lauren 2 lecture
  hall\, Medisiina D\nTitle: Intracellular GTP gradients: an unrecognized r
 egulator of cancer progression.\n\nAbstract: In this seminar\, Dr. Nikifor
 ov will discuss how alterations in the biosynthesis of guanosine triphosph
 ate (GTP)—a fundamental but relatively understudied nucleotide—affect 
 key properties of metastatic melanoma cells\, including activity of G-prot
 eins\, invasion\, and metastasis. The data will be presented on how altera
 tions in the biosynthesis of a fundamental\, and yet relatively understudi
 ed molecule\, nucleotide guanosine triphosphate (GTP)\, controls multiple 
 properties of metastatic melanoma cells\, including motility\, invasion an
 d metastasis. Further\, he will describe the construction and characteriza
 tion of genetically encoded ratiometric fluorescent sensors of free intrac
 ellular GTP.  For the first time\, these sensors made possible the visual
 ization of spatio-temporal changes in GTP levels in live cells and shed li
 ght on the molecular mechanisms regulating cancer cell invasion.\n\nAbout 
 the speaker: Dr. Mikhail Nikiforov is a Professor of Pathology with tenure
  at the Duke University School of Medicine and a Professor in the Departme
 nt of Biomedical Engineering at the Duke Pratt School of Engineering. He e
 arned his BS/MS degrees from Lomonosov Moscow State University in 1992 and
  received a Ph.D. in mammalian genetics from the University of Illinois at
  Chicago in 1997.\n\nDr. Nikiforov’s research focuses on identifying and
  pharmacologically targeting the metabolic vulnerabilities of cancer cells
 \, with a particular emphasis on GTP and lipid metabolism. His team uses m
 etastatic melanoma and multiple myeloma as model systems—two malignancie
 s for which the metabolic drivers of tumor progression are not well unders
 tood and for which no curative treatments currently exist.\n\nHis work has
  been published in Blood\, Leukemia\, Nature Methods\, Cancer Cell\, Natur
 e Communications\, Journal of Clinical Investigation\, and other leading j
 ournals.
ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/Mikha
 il_Nikiforov.jpg
CATEGORIES:Events in English,Tapahtumat
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
BEGIN:DAYLIGHT
DTSTART:20250330T040000
TZOFFSETFROM:+0200
TZOFFSETTO:+0300
TZNAME:EEST
END:DAYLIGHT
END:VTIMEZONE
END:VCALENDAR