BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:379@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20241105T130000 DTEND;TZID=Europe/Helsinki:20241105T140000 DTSTAMP:20241101T080242Z URL:https://inflames.utu.fi/events/guest-seminar-professor-susanna-fagerho lm/ SUMMARY:Guest seminar: Professor Susanna Fagerholm DESCRIPTION:Guest seminar: Professor Susanna Fagerholm\nFaculty of Bio- and Environmental Sciences\, University of Helsinki\n\nTitle: "Dendritic ce ll mechanical immune memory"\nWhere: Arje Scheinin lecture hall\, Dentalia building\nWhen: Tuesday\, November 5\, 13:00 – 14:00\nHost: Pieta Matti la\n\nAbout the speaker:\n\n\n\nSusanna Fagerholm is Professor of Cell and Molecular Biology at Faculty of Bio- and Environmental Sciences\, Univers ity of Helsinki. She heads the Integrins in immunity research group. The g roup’s current main research interest lays in investigating how mechanic al interactions of myeloid immune cells with their tissue microenvironment regulates their function. We focus mainly on dendritic cells\, the main a ntigen presenting cells of the immune system. We propose that cellular int eractions with the microenvironment play more important roles in regulatin g immune cell programming than previously thought\, through so called “ mechanical immune memory”. The immune cell “remembers” its mechanica l interactions with the environment through epigenetic and metabolic effec ts\, which impacts on immune cell gene expression\, programming and cell f unction. Loss of cell adhesion to the microenvironment may constitute a ne w “danger signal” that induces myeloid cell reprogramming and increase d immune responses in vivo.\n\n\n\nSelected publications:\n\n Harjunpää H\, Somermäki R\, Saldo Rubio G\, Fusciello M\, Feola S\, Faisal I\, Nie minen AI\, Wang L\, Llort Asens M\, Zhao H\, Eriksson O\, Cerullo V\, & \; Fagerholm SC. Loss of β2-integrin function results in metabolic reprog ramming of dendritic cells\, leading to increased dendritic cell functiona lity and anti-tumor responses. OncoImmunology\, 13(1):2369373\n Harjunpä ä H\, Tallberg R\, Cui Y\, Guenther C\, Liew HK\, Seelbach A\, Saldo Rubi o G\, Airavaara M\, Fagerholm SC. β2-Integrins Regulate Microglial Resp onses and the Functional Outcome of Hemorrhagic Stroke In Vivo. J Immunol . 213(4):519-525.\n Fagerholm SC. 2022. Integrins in health and diseases. New Engl J Med. 387:1519-1521.\n Guenther C\, Faisal I\, Fusciello M\, S okolova M\, Ilander M\, Harjunpää H\, Tallberg R\, Vartiainen M\, Gonzal ez-Granado J-M\, Alon R\, Cerullo V\, Fagerholm SC. 2021. β2-integrin adh esion regulate dendritic cell epigenetic and transcriptional landscapes to restrict dendritic cell maturation and tumour rejection. Cancer Immunol R es. 9:1354–69\n Savinko T\, Guenther C\, Uotila L\, Llort Asens M\, Yao S\, Tojkander S\, Fagerholm SC. 2018. Filamin A is required for optimal T cell integrin-mediated force transmission\, flow adhesion and T cell traf ficking. J Immunol. 200(9):3109-3116.\n Morrison VL\, James MJ\, Grzes K\ , Cook P\, Glass DG\, Lek HS\, Gawden-Bone C\, Watts C\, Millington OR\, M acDonald AS\, Fagerholm SC. 2014. Loss of beta2-integrin-mediated cytoskel etal linkage reprograms dendritic cells to a mature migratory phenotype. N at Commun. 5: 5359.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/Susan na_Fagerholm.png CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR