BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.5//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:511@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20261210T120000 DTEND;TZID=Europe/Helsinki:20261210T130000 DTSTAMP:20260930T063553Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-thomas-helled ay/ SUMMARY:Frontiers of Science: Prof. Thomas Helleday DESCRIPTION:10th December at 12:00\nOnsite event\nin Presidentti auditorium \, BioCity\nAutumn 2026 poster\n\nProf. Thomas Helleday\, Karolinska Insti tutet\, Sweden\nTargeting cancer by oncogenic trapping: From bench to clin ical trials\n\nHost: Jukka Westermarck (jukka.westermarck@utu.fi)\n\nCoffe e and sandwich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have lunch and d iscuss with Prof. Helleday after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections f or future. Everyone is welcome to join\, BioCity Turku will offer the lunc h.\n\nIf you got interested in joining the lunch\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nThomas Helleday is a Professor o f Chemical Biology in Karolinska Institutet\, Sweden. In his research\, he is focusing on exploiting the weaknesses of cancer cells in DNA repair an d altered metabolism. His research group uses genetic tools and develops p robes to study identified target proteins more closely. By selectively inh ibiting DNA repair or proteins that are crucial for the growth of cancer c ells\, the researchers tailor new treatment methods against cancer.\n\n&nb sp\;\n\nSelected publications\n\nMortusewicz O\, Haslam J\, Gad H\, Helled ay T. Uracil-induced replication stress drives mutations\, genome instabil ity\, anti-cancer treatment efficacy\, and resistance. Mol Cell. 2025 May 15\;85(10):1897-1906\n\nGreen AC\, Marttila P\, Kiweler N\, …\, Sandberg L\, Frödin M\, Moussay E\, Slipicevic A\, Letellier E\, Paggetti J\, Sø rensen CS\, Helleday T\, Henriksson M\, Meiser J. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Ap r\;5(4):642-659.\n\nMarklund M\, Schultz N\, Friedrich S\, Berglund E\, Ta rish F\, Tanoglidi A\, Liu Y\, Bergenstråhle L\, Erickson A\, Helleday T\ , Lamb AD\, Sonnhammer E\, Lundeberg J. Spatio-temporal analysis of prosta te tumors in situ suggests pre-existence of treatment-resistant clones. Na t Commun. 2022 Sep 17\;13(1):5475\n\nMichel M\, Benítez-Buelga C\, Calvo PA\, …\, Vilotijevic I\, Kalderén C\, Osorio A\, Perona R\, Stolz A\, S tenmark P\, Berglund UW\, de Vega M\, Helleday T. Small-molecule activatio n of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24\;376(6600):1471-1476\n\n \;\n\nGeneral informati on\n\n Registration is not needed\, participation list is circulated in t he audience.\n If you are a student and later wish to get a certificate o f attendance from the Frontier of Science seminars (BKEM1020\; UTU)\, prin t out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note t hat any audio or video recording of the seminars is strictly forbidden.\n Autumn 2026 image credits to Samuel Svärd: Whole mount immunofluorescent staining of the mouse retina. Image acquired on 3i CSU-W1 Spinning disk w ith 10x objective.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/helle day-thumbnail.jpg CATEGORIES:Events in English LOCATION:Presidentti auditorium\, BioCity\, Turku\, Finland X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=BioCity\, Turku\, Finland;X -APPLE-RADIUS=100;X-TITLE=Presidentti auditorium:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20261025T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR