BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.14//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:511@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20261210T120000 DTEND;TZID=Europe/Helsinki:20261210T140000 DTSTAMP:20261104T113650Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-thomas-helled ay/ SUMMARY:Frontiers of Science and LUNCH: Prof. Thomas Helleday DESCRIPTION:10th December at 12:00 and free lunch at 13:00\nOnsite event\ni n Presidentti auditorium\, BioCity\nAutumn 2026 poster\n\nProf. Thomas Hel leday\, Karolinska Institutet\, Sweden\nTargeting cancer by oncogenic trap ping: From bench to clinical trials\n\nHost: Jukka Westermarck (jukka.west ermarck@utu.fi)\n\n \;\n\nNo coffees nor sandwiches\, but lunch for 15 0 first ones to sign up\, right after the FoS talk\, in BioCity lobby\, as a thank you for being active members of BioCity Turku. Everyone is welcom e to join\, register here: https://link.webropolsurveys.com/S/D6C3D85639FB E114\n\nSix PhD researchers and early-career postdocs are welcome to share a lunch table and discuss with Prof. Helleday after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. If you got interested\, please send an emai l to biocityturku@bioscience.fi\n\n \;\n\nThomas Helleday is a Profess or of Chemical Biology in Karolinska Institutet\, Sweden. In his research\ , he is focusing on exploiting the weaknesses of cancer cells in DNA repai r and altered metabolism. His research group uses genetic tools and develo ps probes to study identified target proteins more closely. By selectively inhibiting DNA repair or proteins that are crucial for the growth of canc er cells\, the researchers tailor new treatment methods against cancer.\n\ n \;\n\nSelected publications\n\nMortusewicz O\, Haslam J\, Gad H\, He lleday T. Uracil-induced replication stress drives mutations\, genome inst ability\, anti-cancer treatment efficacy\, and resistance. Mol Cell. 2025 May 15\;85(10):1897-1906\n\nGreen AC\, Marttila P\, Kiweler N\, …\, Sand berg L\, Frödin M\, Moussay E\, Slipicevic A\, Letellier E\, Paggetti J\, Sørensen CS\, Helleday T\, Henriksson M\, Meiser J. Formate overflow dri ves toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 202 3 Apr\;5(4):642-659.\n\nMarklund M\, Schultz N\, Friedrich S\, Berglund E\ , Tarish F\, Tanoglidi A\, Liu Y\, Bergenstråhle L\, Erickson A\, Helleda y T\, Lamb AD\, Sonnhammer E\, Lundeberg J. Spatio-temporal analysis of pr ostate tumors in situ suggests pre-existence of treatment-resistant clones . Nat Commun. 2022 Sep 17\;13(1):5475\n\nMichel M\, Benítez-Buelga C\, Ca lvo PA\, …\, Vilotijevic I\, Kalderén C\, Osorio A\, Perona R\, Stolz A \, Stenmark P\, Berglund UW\, de Vega M\, Helleday T. Small-molecule activ ation of OGG1 increases oxidative DNA damage repair by gaining a new funct ion. Science. 2022 Jun 24\;376(6600):1471-1476\n\n \;\n\nGeneral infor mation\n\n Registration is not needed\, participation list is circulated in the audience.\n If you are a student and later wish to get a certifica te of attendance from the Frontier of Science seminars (BKEM1020\; UTU)\, print out the seminar diary and after the seminar ask the BioCity coordina tor to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please no te that any audio or video recording of the seminars is strictly forbidden .\n Autumn 2026 image credits to Samuel Svärd: Whole mount immunofluores cent staining of the mouse retina. Image acquired on 3i CSU-W1 Spinning di sk with 10x objective.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/helle day-thumbnail.jpg CATEGORIES:Events in English LOCATION:Presidentti auditorium\, BioCity\, Turku\, Finland X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=BioCity\, Turku\, Finland;X -APPLE-RADIUS=100;X-TITLE=Presidentti auditorium:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20261025T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR