BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:461@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20260521T120000 DTEND;TZID=Europe/Helsinki:20260521T130000 DTSTAMP:20260324T072713Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-sussan-noursh argh/ SUMMARY:Frontiers of Science: Prof. Sussan Nourshargh DESCRIPTION:21st May 2026 at 12:00\nOnsite event\nin Presidentti auditorium \, BioCity\nSpring 2026 program\n\nProf. Sussan Nourshargh\, Queen Mary Un iversity of London\, UK\nNeutrophil breaching of microvessels: Regulation &\; dysregulation\n\nHost: Sirpa Jalkanen (sirjal@utu.fi)\n\nCoffee and sandwich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and disc uss with Prof. Nourshargh after the seminar. This is a great possibility t o learn hosting skills in a friendly environment and create connections fo r future. Everyone is welcome to join\, BioCity Turku will offer the lunch .\n\nIf you got interested\, please send an email to biocityturku@bioscien ce.fi\n\n \;\n\nNoursharg lab aims to unravel the cellular and molecul ar basis of several fundamental aspects of immunity\, inflammation and vas cular biology. Most notably the team has made internationally rated contri butions to the mechanisms through which white blood cells (in particular n eutrophils) breach blood vessel walls to enter inflamed tissues.​ Princi pal research objectives include i) investigations into the molecular and c ellular basis of white blood cell trafficking (in particular neutrophils) in response to inflammatory insults ii) Exploring the interplay between va scular\, tissue and immune cells that regulate vascular integrity and func tion\, and iii) investigating the above fundamental concepts under physiol ogical and pathological conditions and in response to ageing. ​The team employs a multidisciplinary approach in addressing its objectives and in p articular applies advanced microscopy techniques (e.g. confocal intravital microscopy) to analyse white blood cell behaviours in relation to blood v essel walls.\n\n \;\n\nSelected publications\n\nRolas L\, Stein M\, Ba rkaway A\, …\, Gaston-Massuet C\, Fossati-Jimack L\, Pitzalis C\, Cooper D\, Nightingale TD\, Lopez-Otin C\, Lewis MJ\, Nourshargh S. 2024. Senesc ent endothelial cells promote pathogenic neutrophil trafficking in inflame d tissues. EMBO Rep. 2024 Sep\;25(9):3842-3869\n\nBenedicto I\, Carmona RM \, Barettino A\, Espinós-Estévez C\, Gonzalo P\, Nevado RM\, de la Fuent e-Pérez M\, Andrés-Manzano MJ\, González-Gómez C\, Rolas L\, Dorado B\ , Nourshargh S\, Hamczyk MR\, Andrés V. 2024. Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscl e cells but not endothelial cells. Proc Natl Acad Sci U S A. 2024 Apr 30\; 121(18):e2400752121.\n\nJoulia R\, Guerrero-Fonseca IM\, Girbl T\, Coates JA\, Stein M\, Vázquez-Martínez L\, Lynam E\, Whiteford J\, Schnoor M\, Voehringer D\, Roers A\, Nourshargh S\, Voisin MB. 2022. Neutrophil breach ing of the blood vessel pericyte layer during diapedesis requires mast cel l-derived IL-17A. Nat Commun. 2022 Nov 17\;13(1):7029.\n\nReglero-Real N\, Pérez-Gutiérrez L\, Yoshimura A\, …\, Nightingale TD\, Collinson L\, Perretti M\, Aksoy E\, Nourshargh S. 2021. Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity . 2021 Sep 14\;54(9):1989-2004.e9\n\nReglero-Real N\, Rolas L\, Nourshargh S. 2019. Leukocyte Trafficking: Time to Take Time Seriously. Immunity. 20 19 Feb 19\;50(2):273-275.\n\n \;\n\nGeneral information\n\n Registrat ion is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after t he seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/f /0cd08ce7e61b419b88cb/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2026 image credits to Jan K aslin: Motor neurons (green) and newly produced cells (red) are organized around the central canal (blue cells surrounding channel that crosses the image) in the adult zebrafish spinal cord. Image taken using Leica SP8 con focal microscope.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/fos-s pring2026-thumbnail.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20260329T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR