BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:390@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20250306T120000 DTEND;TZID=Europe/Helsinki:20250306T130000 DTSTAMP:20250117T122659Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-simon-robson/ SUMMARY:Frontiers of Science: Prof. Simon Robson DESCRIPTION:Frontiers of Science\n\nMarch 6th at 12:00\nOnsite event\nin Pr esidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Simon Robson\ , Harvard Medical School\, USA\nReciprocal targeting of ENTPD/CD39 ectonu cleotidases to inflame tumors and restore homeostasis\nHost: Gennady Yegut kin (genyeg@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first ser ved!\n\n \;\n\nSix PhD researchers and early-career postdocs are welco me to have a lunch and discuss with Prof. Robson after the seminar. This i s a great possibility to learn hosting skills in a friendly environment an d create connections for future. Everyone is welcome to join\, BioCity Tur ku will offer the lunch.\n\nIf you got interested\, please send an email t o biocityturku@bioscience.fi\n\n \;\n\nSimon Robson is a globally reco gnized leader in the field of purinergic signaling\, holds the prestigious Charlotte F. and Irving W. Rabb Professorship of Medicine in Harvard and serves as Vice Chair of Research in the Department of Anesthesia\, Critica l Care at Beth Israel Deaconess Medical Center. Dr. Robson’s pioneering work on ectonucleotidases\, particularly CD39\, has revealed its crucial r oles in T cells and endothelial cells\, with broad implications for chroni c inflammatory diseases\, cancer\, and transplantation. His foundational d iscoveries have had substantial translational impact\, with ongoing clinic al trials exploring CD39-targeted therapies for cancer. His current resear ch continues to expand knowledge of purinergic signaling in immune-related diseases\, including cancer and inflammatory bowel disease\, with promisi ng potential for clinical application. Dr. Robson’s combined scientific and medical expertise makes his talk highly relevant to both scientists an d clinicians.\n\n \;\n\nSelected publications\n\nFeng L\, Zhang H\, Ma o C\, De Andrade Mello P\, Stroopinsky D\, Csizmadia E\, Zhou J\, Avigan D \, Yu J\, Gao W\, Robson SC. Cd39 and P2rx7-Wnt signaling enhance blast pa thogenicity in an experimental model of acute myeloid leukemia. Haematolog ica. 2024 Aug 15. doi: 10.3324/haematol.2024.285547.\n\nVignali PD DePeaux K\, Watson MJ\, Ye C\, Ford BR\, Lontos K\, McGaa NK\, Scharping NE\, Men k AV\, Robson SC\, Poholek AC\, Rivadeneira DB\, Delgoffe GM. Hypoxia driv es CD39-dependent suppressor function in exhausted T cells to limit antitu mor immunity. Nat Immunol. 2023 Feb\;24(2):267-279. doi: 10.1038/s41590-02 2-01379-9.\n\nZhang H\, Feng L\, de Andrade Mello P\, Mao C\, Near R\, Csi zmadia E\, Chan LL\, Enjyoji K\, Gao W\, Zhao H\, Robson SC. Glycoengineer ed anti-CD39 promotes anticancer responses by depleting suppressive cells and inhibiting angiogenesis in tumor models. J Clin Invest. 2022 Jul 1\;13 2(13):e157431. doi: 10.1172/JCI157431.\n\nSandhu B\, Perez-Matos MC\, Tran S\, Singhal G\, Syed I\, Feldbrügge L\, Mitsuhashi S\, Pelletier J\, Hua ng J\, Yalcin Y\, Csizmadia E\, Tiwari-Heckler S\, Enjyoji K\, Sévigny J\ , Maratos-Flier E\, Robson SC\, Jiang ZG. Global deletion of NTPDase3 prot ects against diet-induced obesity by increasing basal energy metabolism. M etabolism. 2021 May\;118:154731. doi: 10.1016/j.metabol.2021.154731.\n\nHa rshe RP\, Xie A\, Vuerich M\, Frank LA\, Gromova B\, Zhang H\, Robles RJ\, Mukherjee S\, Csizmadia E\, Kokkotou E\, Cheifetz AS\, Moss AC\, Kota SK\ , Robson SC\, Longhi MS. Endogenous antisense RNA curbs CD39 expression in Crohn's disease. Nat Commun. 2020 Nov 18\;11(1):5894. doi: 10.1038/s41467 -020-19692-y.\n\nDwyer KM\, Kishore BK\, Robson SC. Conversion of extracel lular ATP into adenosine: a master switch in renal health and disease. Nat Rev Nephrol. 2020 Sep\;16(9):509-524. doi: 10.1038/s41581-020-0304-7.\n\n  \;\n\nGeneral information\n\n You can download and save all the spri ng 2025 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/ 44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list i s circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar ask the BioCity coordinator t o sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note th at any audio or video recording of the seminars is strictly forbidden.\n Spring 2025 image credits to Teemu Tuominen: Close up photograph of soil b acteria Streptomyces colonies border.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/robso n400px.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR