BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:210@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20230209T120000 DTEND;TZID=Europe/Helsinki:20230209T130000 DTSTAMP:20230127T160928Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-rene-bernards / SUMMARY:Frontiers of Science: Prof. Rene Bernards DESCRIPTION:\n\nFebruary 9th at 12:00\non-site event\nPresidentti auditoriu m\, BioCity\nSpring 2023 program\n\nProf. Rene Bernards\, Netherlands Canc er Institute\, Netherlands\nUnconventional approaches to cancer therapy\nH ost: Klaus Elenius (klaele@utu.fi)\n\nCoffee and sandwich served at 11:45\ n\n \;\n\nResearch group of Prof. Bernards uses genome-wide functional genetic approaches to identify powerful drug combinations\, new drug targ ets and mechanisms of resistance to cancer drugs. They focus on induction of senescence as a new therapeutic modality for cancer therapy. In additio n\, the group studies how combinations of drugs that act in the MAP kinase pathway can help improve responses in patients with perturbations of this pathway. Prof. Bernard’s group aims to bring their discoveries to the c linic in close collaboration with the clinicians of their affiliated hospi tal.\n\n \;\n\nSelected publications\n\nJin H\, Wang L\, Bernards R. 2 022. Rational combinations of targeted cancer therapies: background\, adva nces and challenges. Nat Rev Drug Discov\, in press\n\nNowak-Sliwinska P\, van Beijnum JR\, Griffioen CJ\, Huinen ZR\, Sopesens NG\, Schulz R\, Jenk ins SV\, Dings RPM\, Groenendijk FH\, Huijbers EJM\, Thijssen VLJL\, Jonas ch E\, Vyth-Dreese FA\, Jordanova ES\, Bex A\, Bernards R\, de Gruijl TD\, Griffioen AW. 2022. Proinflammatory activity of VEGF-targeted treatment t hrough reversal of tumor endothelial cell anergy. Angiogenesis\, in press\ n\nWang L\, Jin H\, Jochems F\, Wang S\, Lieftink C\, Martinez IM\, De Con ti G\, Edwards F\, de Oliveira RL\, Schepers A\, Zhou Y\, Zheng J\, Wu W\, Zheng X\, Yuan S\, Ling J\, Jastrzebski K\, Santos Dias MD\, Song JY\, Ce lie PNH\, Yagita H\, Yao M\, Zhou W\, Beijersbergen RL\, Qin W\, Bernards R. 2022. cFLIP suppression and DR5 activation sensitize senescent cancer c ells to senolysis. Nat Cancer. 3: 1284-1299\n\nWang L\, Lankhorst L\, Bern ards R. 2022. Exploiting senescence for the treatment of cancer. Nat Rev C ancer. 22: 340-355\n\n \;\n\nGeneral information\n\n You can download all spring 2023 FoS-seminars in your calendar from here: https://seafile. utu.fi/d/4a0b831f23ef420786b0/\n Registration is not needed for the on-si te seminars\n Participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the F rontier of Science seminars\, please print out this seminar diary and afte r the seminar ask the BioCity coordinator to sign it\n Please note that a ny audio or video recording of the seminars is strictly forbidden.\n ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/2023/ 01/bernards-400x400-1.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20221030T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR