BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:458@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20260416T120000 DTEND;TZID=Europe/Helsinki:20260416T130000 DTSTAMP:20260324T072442Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-paul-timpson/ SUMMARY:Frontiers of Science: Prof. Paul Timpson DESCRIPTION:16th April 2026 at 12:00\nOnsite event\nin Presidentti auditori um\, BioCity\nSpring 2026 program\n\nProf. Paul Timpson\, Garvan Institute of Medical Research\, Australia\nIntravital imaging of cancer and drug re sponses\n\nHost: Johanna Ivaska (joivaska@utu.fi)\n\nCoffee and sandwich s erved at 11:45\, first come first serve!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Pr of. Timpson after the seminar. This is a great possibility to learn hostin g skills in a friendly environment and create connections for future. Ever yone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you go t interested\, please send an email to biocityturku@bioscience.fi\n\n  \;\n\nCancer invasion and metastasis occur in a complex three-dimensional environment\, with reciprocal feedback from the surrounding host tissue an d stroma governing cancer cell behaviour. Understanding this behaviour in an intact host setting allows us to examine – in a more physiological co ntext – the aberrant regulation of critical events that lead to the diss emination and spread of the primary tumour. Intravital (in vivo) imaging i s providing new insights into how cells behave in their native microenviro nment\, thereby improving our understanding of disease progression.\n\nTim pson lab uses novel state-of-the-art intravital imaging approaches and new fluorescent biosensor mouse models to uncouple the metastatic process int o key stages\, in order to pinpoint critical events that drive tumour inva sion and metastasis. Their approach allows real-time imaging\, ranging fro m whole body tumour progression to single-cell invasion events. This helps to understand how tumour cell dissociation\, invasion or progression are controlled and how this regulation is linked to the development of invasiv e or metastatic cancer.\n\nTimpson lab also explores properties of the thr ee-dimensional tumour microenvironment that contribute to poor drug target ing\, in order to pinpoint critical barriers that impair treatment. The te am then employs combination therapy aimed at counteracting these barriers\ , to enhance drug penetrance and efficiency in vivo\, and improve overall drug delivery outcomes.\n\n \;\n\nSelected publications\n\nChambers CR \, Watakul S\, Schofield P\, Howell AE\, …\, Wang Y\, Joshua AM\, Chantr ill L\, Evans TRJ\, Gill AJ\, Morton JP\, Pajic M\, Christ D\, Herzog H\, Timpson P\, Herrmann D. 2025. Targeting the NPY/NPY1R signaling axis in mu tant p53-dependent pancreatic cancer impairs metastasis. Sci Adv. 2025 Mar 14\;11(11):eadq4416.\n\n \;\n\nPereira BA\, Ritchie S\, Chambers CR\, Gordon KA\, …\, Herrmann D\, Cox TR\, Timpson P. 2024. Temporally resol ved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer tha t modulates fibrosis and therapy response. Sci Adv. 2024 Jul 5\;10(27):ead l1197.\n\nBhattacharyya ND\, Kyaw W\, McDonald MM\, Dhenni R\, Grootveld A K\, Xiao Y\, Chai R\, Khoo WH\, Danserau LC\, Sergio CM\, Timpson P\, Lee WM\, Croucher PI\, Phan TG. 2023. Minimally invasive longitudinal intravit al imaging of cellular dynamics in intact long bone. Nat Protoc. 2023 Dec\ ;18(12):3856-3880.\n\nChitty JL\, Yam M\, Perryman L\, Parker AL\, Skhinas JN\, Setargew YFI\, …\, Australian Pancreatic Cancer Matrix Atlas (APMA )\; Pajic M\, Timpson P\, Jarolimek W\, Cox TR. 2023. A first-in-class pan -lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabi ne response and survival in pancreatic cancer. Nat Cancer. 2023 Sep\;4(9): 1326-1344.\n\nConway JRW\, Warren SC\, Lee YK\, McCulloch AT\, …\, Papa A\, Haigh JJ\, Nobis M\, Timpson P. 2023. Monitoring AKT activity and targ eting in live tissue and disease contexts using a real-time Akt-FRET biose nsor mouse. Sci Adv. 2023 Apr 28\;9(17):eadf9063.\n\n \;\n\nGeneral in formation\n\n Registration is not needed\, participation list is circulat ed in the audience\n If you are a student and later wish to get a certifi cate of attendance from the Frontier of Science seminars\, print out the s eminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/f/0cd08ce7e61b419b88cb/\n Please note that any aud io or video recording of the seminars is strictly forbidden.\n Spring 202 6 image credits to Jan Kaslin: Motor neurons (green) and newly produced ce lls (red) are organized around the central canal (blue cells surrounding c hannel that crosses the image) in the adult zebrafish spinal cord. Image t aken using Leica SP8 confocal microscope.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/fos-s pring2026-thumbnail.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20260329T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR