BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:319@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20240523T120000 DTEND;TZID=Europe/Helsinki:20240523T130000 DTSTAMP:20240507T113432Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-michael-o-hot tiger/ SUMMARY:Frontiers of Science: Prof. Michael O. Hottiger DESCRIPTION:\n\nMay 23rd at 12:00\nOn-site event\nPresidentti auditorium\, BioCity\nSpring 2024 program\n\nProf. Michael O. Hottiger\, University of Zurich\, Switzerland\nUncovering ADP-ribosylation signaling pathways: impl ications for PARP7 in cancer\nHost: Lea Sistonen (lea.sistonen@abo.fi)\n\n Coffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch in r estaurant Mauno and discuss with Prof. Hottiger after the seminar. This is a great possibility to learn hosting skills in friendly environment and c reate connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to b iocityturku@bioscience.fi\n\n \;\n\nHottiger lab investigates inflamma tory signaling (e.g. oxidative stress) with special focus on the role of p ost-translations modifications (PTM) such as ADP-ribosylation in the regul ation of inflammation. PTMs of proteins are thought to contribute to the o bserved complexity of cellular processes in animal and man. PTMs may help to explain the differences between e.g. worm and man\, considering that th e number and the nucleotide sequences of genes is rather comparable among animal species. Hottiger lab studies the patterns of ADP-ribosylation usin g cutting-edge systems biology approaches such as ADP-ribosyl-specific hig h-resolution and quantitative mass spectrometry that are developed in hous e or in collaboration with various colleagues worldwide. Furthermore\, Hot tiger lab investigates the players involved\, such as writers\, readers an d eraser of ADP-ribosylation\, as well as their target proteins that carry this PTM using state-of-the-art proteomics methods.\n\n \;\n\nSelecte d publications\n\nMuskalla L\, Güldenpfennig A\, Hottiger MO. Subcellular Quantitation of ADP-Ribosylation by High-Content Microscopy. 2023. Method s Mol Biol. 2023\;2609:101-109. doi: 10.1007/978-1-0716-2891-1_7\n\nSchram l P\, Aimi F\, Zoche M\, Aguilera-Garcia D\, Arnold F\, Moch H\, Hottiger MO. 2023. Altered cytoplasmic and nuclear ADP-ribosylation levels analyzed with an improved ADP-ribose binder are a prognostic factor in renal cell carcinoma. J Pathol Clin Res. 2023 Mar 31. doi: 10.1002/cjp2.320\n\nLiu L\ , Sandow JJ\, Leslie Pedrioli DM\, Samson AL\, Silke N\, Kratina T\, Ambro se RL\, Doerflinger M\, Hu Z\, Morrish E\, Chau D\, Kueh AJ\, Fitzibbon C\ , Pellegrini M\, Pearson JS\, Hottiger MO\, Webb AI\, Lalaoui N\, Silke J. 2022. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced d eath. Sci Adv. 2022 May 13\;8(19):eabh2332. doi: 10.1126/sciadv.abh2332\n\ n \;\n\nGeneral information\n\n You can download and save all the spr ing 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d /44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to ge t a certificate of attendance from the Frontier of Science seminars\, prin t out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note t hat any audio or video recording of the seminars is strictly forbidden.\n Spring 2024 FoS image credits to Jenny Pessa: Transformed human breast ep ithelial HS578T cells (flattened)\, labelled with commercial fluorescent a ntibodies. Image acquired on 3i CSU-W1 Spinning disk with 40x objective.\n \n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/hotti ger-400.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR