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UID:320@inflames.utu.fi
DTSTART;TZID=Europe/Helsinki:20240229T120000
DTEND;TZID=Europe/Helsinki:20240229T130000
DTSTAMP:20231220T114000Z
URL:https://inflames.utu.fi/events/frontiers-of-science-prof-juha-klefstro
 m-2/
SUMMARY:Frontiers of Science: Prof. Juha Klefström
DESCRIPTION:\n\nFebruary 29th at 12:00\nOn-site event\nPresidentti auditori
 um\, BioCity\nSpring 2024 program\n\nProf. Juha Klefström\, University of
  Helsinki\, Finland\nOf MYC\, mitochondrial metabolism and death – It’
 s better to burn out than fade away\nHost: Jukka Westermarck (jukwes@utu.f
 i)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n&nbsp\;\n
 \nSix PhD researchers and early-career postdocs are welcome to have a lunc
 h in restaurant Mauno and discuss with Prof. Klefström after the seminar.
  This is a great possibility to learn hosting skills in friendly environme
 nt and create connections for future. Everyone is welcome to join\, BioCit
 y Turku will offer the lunch.\n\nIf you got interested\, please send an em
 ail to biocityturku@bioscience.fi\n\n&nbsp\;\n\nJuha Klefström is a FICAN
  Research Professor in Finnish Cancer Institute\, a part time Professor in
  FICAN-South (HUS) and a part time Research Director in the Translational 
 Cancer Medicine Program\, Medical Faculty\, University of Helsinki. Klefst
 röm is an expert in translational cancer research\, breast cancer biology
 \, immuno-oncology\, oncogenes and tumor suppressors\, cell death\, geneti
 cally engineered mouse models of breast cancer\, mammary gland reconstitut
 ion techniques\, ex vivo explant cultures and recombinant viral gene trans
 fer methods. Klefström’s research focuses on therapeutic strategies aim
 ing to exploit oncogene-induced vulnerabilities and he has long-term inter
 est in the apoptotic function of MYC protein. Currently\, his research gro
 up explores the potential of oncogenic MYC in triggering immunogenic death
  of the tumor cells. Klefström’s research group has established variety
  of three-dimensional culture systems for mammary primary and stem cell-ba
 sed organotypic breast structures as well as patient tumor-derived explant
 s for ex vivo target validation and for studies of breast cancer developme
 nt and translation.\n\n&nbsp\;\n\nSelected publications\n\nMunne PM\, Mart
 ikainen L\, Räty I\, Bertula K\, …\, Monni O\, Pouwels J\, Sahu B\, Mat
 tson J\, Joensuu H\, Heikkilä P\, Elo LL\, Metcalfe C\, Junttila MR\, Ikk
 ala O\, Klefström J. 2021. Compressive stress-mediated p38 activation req
 uired for ERα + phenotype in breast cancer. Nat Commun. 2021 Nov 29\;
 12(1):6967. doi: 10.1038/s41467-021-27220-9\n\nTervonen TA\, Pant SM\, Bel
 itškin D\, Englund JI\, Närhi K\, Haglund C\, Kovanen PE\, Verschuren EW
 \, Klefström J. 2021. Oncogenic Ras Disrupts Epithelial Integrity by Acti
 vating the Transmembrane Serine Protease Hepsin. Cancer Res. 2021 Mar 15\;
 81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760\n\nHaikala HM\, Anttil
 a JM\, Marques E\, …\, Mustjoki S\, Kovanen P\, Eilers M\, Leverson JD\,
  Klefström J. 2019. Pharmacological reactivation of MYC-dependent apoptos
 is induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019 Feb
  6\;10(1):620. doi: 10.1038/s41467-019-08541-2\n\n&nbsp\;\n\nGeneral infor
 mation\n\n 	You can download and save all the spring 2024 FoS-seminars to 
 your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n 
 	Registration is not needed\, participation list is circulated in the audi
 ence\n 	If you are a student and later wish to get a certificate of attend
 ance from the Frontier of Science seminars\, print out the seminar diary a
 nd after the seminar ask the BioCity coordinator to sign it https://seafil
 e.utu.fi/d/44a70f80ac1e46a9ad0a/\n 	Please note that any audio or video re
 cording of the seminars is strictly forbidden.\n 	Spring 2024 FoS image cr
 edits to Jenny Pessa: Transformed human breast epithelial HS578T cells (fl
 attened)\, labelled with commercial fluorescent antibodies. Image acquired
  on 3i CSU-W1 Spinning disk with 40x objective.\n\n&nbsp\;
ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/klefs
 trom-400.jpg
CATEGORIES:Events in English,Tapahtumat
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