BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:249@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20230504T120000 DTEND;TZID=Europe/Helsinki:20230504T130000 DTSTAMP:20230317T144638Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-johanna-mylly harju-2/ SUMMARY:Frontiers of Science: Prof. Johanna Myllyharju DESCRIPTION:\n\nMay 4th at 12:00\non-site event\nPresidentti auditorium\, B ioCity\nSpring 2023 program\n\nProf. Johanna Myllyharju\, University of Ou lu\, Finland\nHypoxia response and collagen synthesis as therapeutic targe ts\nHost: Jyrki Heino (jyrki.heino@utu.fi)\n\nCoffee and sandwich served a t 11:45\n\n \;\n\nSix students and early-career postdocs are welcome t o have a lunch in restaurant Mauno and discuss with Prof. Myllyharju after the seminar. This is a great possibility to learn hosting skills in frien dly environment and create connections for future. Every student are welco me to join\, in spite of which research group they belong to. BioCity Turk u will offer the lunch.\n\nIf you got interested please send an email to b iocityturku@bioscience.fi\n\n \;\n\nProfessor Johanna Myllyharju is an expert on the key enzymes regulating hypoxia response and extracellular m atrix synthesis. Oxygen and extracellular matrix homeostases are vital for normal functioning of cells and tissues\, and disturbances in their balan ce are associated with many common diseases. Therefore\, detailed informat ion on these enzymes is essential for understanding their molecular mechan isms and biological effects in detail. This has already paved the way towa rds pharmacologic interventions\, exemplified by a longterm industrial col laboration to develop enzyme inhibitors that activate the hypoxia response as therapeutic drugs\, the first one being approved for treatment of seve re anemia of chronic kidney diseases in 2018.\n\n \;\n\nSelected publi cations\n\nOllonen T\, Kurkela M\, Laitakari A\, Sakko S\, Koivisto H\, My llyharju J\, Tanila H\, Serpi R\, Koivunen P. 2022. Activation of the hypo xia response protects mice from amyloid-β accumulation. Cell Mol Life Sci . 2022 Jul 19\;79(8):432.\n\nElamaa H\, Kaakinen M\, Nätynki M\, Szabo Z\ , Ronkainen VP\, Äijälä V\, Mäki JM\, Kerkelä R\, Myllyharju J\, Eklu nd L. 2022. PHD2 deletion in endothelial or arterial smooth muscle cells r eveals vascular cell type-specific responses in pulmonary hypertension and fibrosis. Angiogenesis. 2022 May\;25(2):259-274.\n\nCockman ME\, Lippl K\ , Tian YM\, Pegg HB\, Figg WD Jnr\, Abboud MI\, Heilig R\, Fischer R\, Myl lyharju J\, Schofield CJ\, Ratcliffe PJ. 2019 Lack of activity of recombin ant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. Elife. 2019 Sep 10\;8:e46490\n\n \;\n\nGeneral information\n\n You can downl oad all spring 2023 FoS-seminars in your calendar from here: https://seafi le.utu.fi/d/4a0b831f23ef420786b0/\n Registration is not needed for the on -site seminars\n Participation list is circulated in the audience\n If y ou are a student and later wish to get a certificate of attendance from th e Frontier of Science seminars\, please print out this seminar diary and a fter the seminar ask the BioCity coordinator to sign it\n Please note tha t any audio or video recording of the seminars is strictly forbidden.\n ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/2023/ 01/myllyharju400x400.jpg CATEGORIES:Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20230326T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR