BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:387@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20250327T120000 DTEND;TZID=Europe/Helsinki:20250327T130000 DTSTAMP:20250117T122249Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-gareth-inman/ SUMMARY:Frontiers of Science: Prof. Gareth Inman DESCRIPTION:Frontiers of Science\n\nMarch 27th at 12:00\nOnsite event\nin P residentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Gareth Inman \, Beatson Institute for Cancer Research\, UK\nDeciphering squamous cancer disease progression\nHost: Veli-Matti Kähäri (velkah@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD res earchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Inman after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future . Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\ n \;\n\nThe transforming growth factor beta (TGFβ) superfamily compri ses approximately forty related dimeric polypeptide cytokines including th e bone morphogenetic proteins (BMPs)\, the growth and differentiation fact ors (GDFs)\, activin\, nodal and the TGFβs (TGFβ1\, TGFβ2\, TGFβ3). As well as having vital normal physiological functions during development an d in adult life these factors play pivotal roles in cancer biology acting as potent tumour suppressors or tumour promoters in a context dependent ma nner. Work in Inman laboratory seeks to understand how\, when and where TG F superfamily signalling regulates tumour progression. Dysregulation of TGF signalling is particularly prevalent in squamous cell cancers and this has led the team to begin to decipher the molecular landscape of cuta neous squamous cell carcinoma and its similarities with other squamous tum our subtypes. Inman laboratory’s work focuses on understanding the drive r genes\, pathways and processes that drive squamous cancer disease progre ssion with particular focus on cSCC\, Head and Neck SCC and the “squamou s” subtype of pancreatic cancer using in-vitro\, ex-vivo and in-vivo pre -clinical models.\n\n \;\n\nSelected publications\n\nKiourtis C\, Terr adas-Terradas M\, Gee LM\, May S\, Georgakopoulou A\, …\, Inman GJ\, Cam pbell A\, Barry ST\, Quaglia A\, Morris CM\, LeBeau FEN\, Sansom OJ\, Kirs chner K\, Jalan R\, Oakley F\, Bird TG. 2024 Hepatocellular senescence ind uces multi-organ senescence and dysfunction via TGFβ. Nat Cell Biol. 2024 Nov 13. doi: 10.1038/s41556-024-01543-3.\n\nStrathearn LS\, Spender LC\, Schoenherr C\, Mason S\, Edwards R\, Blyth K\, Inman GJ. C1orf106 (INAVA) Is a SMAD3-Dependent TGF-β Target Gene That Promotes Clonogenicity and Co rrelates with Poor Prognosis in Breast Cancer. Cells. 2024 Sep 12\;13(18): 1530. doi: 10.3390/cells13181530.\n\nCarrasco G\, Stavrou I\, Treanor-Tayl or M\, Beetham H\, Lee M\, Masalmeh R\, Carreras-Soldevila A\, Hardman D\, Bernabeu MO\, von Kriegsheim A\, Inman GJ\, Byron A\, Brunton VG.Oncogene sis. 2024. Involvement of Kindlin-1 in cutaneous squamous cell carcinoma. 2024 Jul 9\;13(1):24. doi: 10.1038/s41389-024-00526-1.\n\nBailey P\, Ridgw ay RA\, Cammareri P\, …\, Dimonitsas E\, Stratigos AJ\, Arron ST\, Wang J\, Blyth K\, Proby CM\, Harwood CA\, Sansom OJ\, Leigh IM\, Inman GJ. 202 3. Driver gene combinations dictate cutaneous squamous cell carcinoma dise ase continuum progression. Nat Commun. 2023 Aug 25\;14(1):5211. doi: 10.10 38/s41467-023-40822-9.\n\nFlanagan DJ\, Amirkhah R\, Vincent DF\, Gunduz N \, …\, Lawler M\, Leedham SJ\, Barry ST\, Inman GJ\, van Rheenen J\, Dun ne PD\, Sansom OJ. 2022. Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressi ve features. Nat Commun. 2022 Dec 7\;13(1):7551. doi: 10.1038/s41467-022-3 5134-3.\n\n \;\n\nGeneral information\n\n You can download and save a ll the spring 2025 FoS-seminars to your calendar from here: https://seafil e.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participa tion list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science semin ars\, print out the seminar diary and after the seminar ask the BioCity co ordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Ple ase note that any audio or video recording of the seminars is strictly for bidden.\n Spring 2025 image credits to Teemu Tuominen: Close up photograp h of soil bacteria Streptomyces colonies border.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/inman 400px.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR