BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:388@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20250227T120000 DTEND;TZID=Europe/Helsinki:20250227T130000 DTSTAMP:20250117T122411Z URL:https://inflames.utu.fi/events/frontiers-of-science-prof-brett-nixon/ SUMMARY:Frontiers of Science: Prof. Brett Nixon DESCRIPTION:Frontiers of Science\n\nFebruary 27th at 12:00\nOnsite event\ni n Presidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Brett Nix on\, The University of Newcastle\; Hunter Medical Research Institute\, Aus tralia\nUnderstanding the origins of health\, pathology and infertility th rough the sperm epigenome\nHost: Petra Sipilä (petra.sipila@utu.fi)\n\nCo ffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix Ph D researchers and early-career postdocs are welcome to have a lunch and di scuss with Prof. Nixon after the seminar. This is a great possibility to l earn hosting skills in a friendly environment and create connections for f uture. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n \nIf you got interested\, please send an email to biocityturku@bioscience. fi\n\n \;\n\nProfessor Brett Nixon is a Senior Research Fellow of the National Health and Medical Research Council of Australia and a Professor of Biology at The University of Newcastle\, Australia. In this position\, he serves as Director of the Priority Research Centre for Reproductive Sci ence and of the Hunter Medical Research Institute Infertility and Reproduc tion Research Program. He has conducted research activity at the basic bio logy / clinical andrology interface\, gaining insights into how sperm gain the function required to fertilise an egg\, and how these processes becom e disrupted in cases of male infertility. His research also focuses on the mechanisms by which environmental and lifestyle factors impact sperm qual ity and the consequences of such changes for embryo development. Prof. Nix on’s research models focus primarily on the male germline\, but the impl ications of this research are of direct relevance to our understanding of cell biology more broadly. A defining feature of his research has been the application of advanced mass spectrometry and next-generation sequencing technologies to dissect changes in the proteomic and epigenomic (small non -coding RNA) landscape of sperm cells elicited by various environmental st ressors. This work has made important contributions to our mechanistic kno wledge of the pathways that both germ cells and their somatic support cell s engage in responding to stressors such as xenobiotics\, oxidative stress \, heat stress\, and chemotherapeutic agents. His current research focuses on the mechanisms by which environmental and lifestyle factors impact spe rm epigenome and the consequences of such changes for embryo development. A particular focus for his current work is to translate this knowledge int o rational therapeutic interventions that mitigate the risk of cellular da mage and prevent sperm dysfunction.\n\n \;\n\nSelected publications\n\ nTrigg N\, Schjenken JE\, Martin JH\, Skerrett-Byrne DA\, Smyth SP\, Berns tein IR\, Anderson AL\, Stanger SJ\, Simpson ENA\, Tomar A\, Teperino R\, Conine CC\, De Iuliis GN\, Roman SD\, Bromfield EG\, Dun MD\, Eamens AL\, Nixon B. Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice. Proc Natl Acad Sci U S A. 2024 Nov 19\;121(47):e2409790121. doi: 10.1073/p nas.2409790121.\n\nSkerrett-Byrne DA\, Anderson AL\, Bromfield EG\, Bernst ein IR\, Mulhall JE\, Schjenken JE\, Dun MD\, Humphrey SJ\, Nixon B. Globa l profiling of the proteomic changes associated with the post-testicular m aturation of mouse spermatozoa. Cell Rep. 2022 Nov 15\;41(7):111655. doi: 10.1016/j.celrep.2022.111655.\n\nTrigg NA\, Skerrett-Byrne DA\, Xavier MJ\ , Zhou W\, Anderson AL\, Stanger SJ\, Katen AL\, De Iuliis GN\, Dun MD\, R oman SD\, Eamens AL\, Nixon B. Acrylamide modulates the mouse epididymal p roteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development. Cell Rep. 2021 Oct 5\;37(1):109787. doi: 10.1016/j.celrep.2021.109787.\n\nXavier MJ\, Roman SD\, Aitken RJ\, Nixon B. Transgenerational inheritance: how impacts to the epigenetic and geneti c information of parents affect offspring health. Hum Reprod Update. 2019 Sep 11\;25(5):518-540. doi: 10.1093/humupd/dmz017.\n\nZhou W\, Stanger SJ\ , Anderson AL\, Bernstein IR\, De Iuliis GN\, McCluskey A\, McLaughlin EA\ , Dun MD\, Nixon B. Mechanisms of tethering and cargo transfer during epid idymosome-sperm interactions. BMC Biol. 2019 Apr 18\;17(1):35. doi: 10.118 6/s12915-019-0653-5. IF 7.4\n\n \;\n\nGeneral information\n\n You can download and save all the spring 2025 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is no t needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Front ier of Science seminars\, print out the seminar diary and after the semina r ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80 ac1e46a9ad0a/\n Please note that any audio or video recording of the semi nars is strictly forbidden.\n Spring 2025 image credits to Teemu Tuominen : Close up photograph of soil bacteria Streptomyces colonies border.\n\n&n bsp\;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/nixon 400px.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR