BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:282@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20231214T120000 DTEND;TZID=Europe/Helsinki:20231214T130000 DTSTAMP:20231127T093506Z URL:https://inflames.utu.fi/events/frontiers-of-science-md-tuomas-tammela/ SUMMARY:Frontiers of Science and after-seminar lunch: MD Tuomas Tammela DESCRIPTION:December 14th at 12:00\nOn-site event\nPresidentti auditorium\n Autumn 2023 program\n\nMD Tuomas Tammela\, Sloan Kettering Institute\; Mem orial Sloan Kettering Cancer Center\, US\nFunctional interrogation of intr a-tumoral heterogeneity\nHost: Klaus Elenius (klaele@utu.fi)\n\n \;\n\ nCoffee at 11:45 and instead of having a sandwich before the seminar\, Bio City Turku wants to thank all the people who have joined us to listen to t he Frontiers of Science seminars during 2023\, and invite you all for a lu nch! Let’s have a lunch all together in BioCity lobby after the seminar at 13:00!\n\nAs always\, no need to register to the seminar\, but if you w ant to join for the lunch please register at latest 10 December: https://l ink.webropolsurveys.com/S/6A9778FB474466DA\n\n \;\n\nThe Tammela lab i s interested in understanding the remarkable phenotypic heterogeneity of c ancer cells within tumors. We approach this question using a combination o f sophisticated genetically engineered mouse models\, single-cell approach es\, tracing and ablation of distinct tumor cell lineages\, CRISPR-mediate d gene regulation\, and advanced imaging techniques. We utilize the except ional resources developed by our MSK collaborators\, such as organoids and xenografts\, for the translation of our findings into new treatments for human cancer. Our goal is to discover pathways that drive distinct cellula r phenotypes and to develop new therapeutic concepts aimed at reducing cel lular heterogeneity in tumors.\n\n \;\n\nSelected publications\n\nM Ki m\, M Panagiotakopoulou\, C Chen\, SB Ruiz\, K Ganesh\, T Tammela\, ...\, 2023. Micro-engineering and nano-engineering approaches to investigate tum our ecosystems. Nature Reviews Cancer\, 1-19\n\nSR Torborg\, Z Li\, JE Cha n\, T Tammela. 2022. Cellular and molecular mechanisms of plasticity in ca ncer. Trends in Cancer 8 (9)\, 735-746\n\nMarjanovic ND\, Hofree M\, Chan JE\, … \, Rekhtman N\, Massion PP\, Poirier JT\, Mazutis L\, Li R\, Lee JH\, Amon A\, Rudin CM\, Jacks T\, Regev A\, Tammela T. (2020). Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. Cancer Cell\ , 38(2):229-246\n\n \;\n\nGeneral information\n\n You can download an d save all the autumn 2023 FoS-seminars to your calendar from here: https: //seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, p articipation list is circulated in the audience\n If you are a student an d later wish to get a certificate of attendance from the Frontier of Scien ce seminars\, print out the seminar diary and after the seminar ask the Bi oCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a /\n Please note that any audio or video recording of the seminars is stri ctly forbidden.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/fos20 23autumn_400px-nelio-1.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20231029T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR