BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:292@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20231214T120000 DTEND;TZID=Europe/Helsinki:20231214T130000 DTSTAMP:20231127T093636Z URL:https://inflames.utu.fi/events/frontiers-of-science-md-tuomas-tammela- 2/ SUMMARY:Frontiers of Science and after-seminar lunch: MD Tuomas Tammela DESCRIPTION:December 14th at 12:00\nOn-site event\nPresidentti auditorium\n Autumn 2023 program\n\nMD Tuomas Tammela\, Sloan Kettering Institute\; Mem orial Sloan Kettering Cancer Center\, US\nFunctional interrogation of intr a-tumoral heterogeneity\nHost: Klaus Elenius (klaele@utu.fi)\n\nCoffee at 11:45\, and instead of having a sandwich before the seminar\, BioCity Turk u wants to thank all the people who have joined us to listen to the Fronti ers of Science seminars during 2023\, and invite you all for lunch! Let’ s have a lunch all together in BioCity lobby after the seminar at 13:00!\n \nAs always\, no need to register to the seminar\, but if you want to join for the lunch please register at latest 10 December: https://link.webropo lsurveys.com/S/6A9778FB474466DA\n\n \;\n\nThe Tammela lab is intereste d in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophistic ated genetically engineered mouse models\, single-cell approaches\, tracin g and ablation of distinct tumor cell lineages\, CRISPR-mediated gene regu lation\, and advanced imaging techniques. We utilize the exceptional resou rces developed by our MSK collaborators\, such as organoids and xenografts \, for the translation of our findings into new treatments for human cance r. Our goal is to discover pathways that drive distinct cellular phenotype s and to develop new therapeutic concepts aimed at reducing cellular heter ogeneity in tumors.\n\n \;\n\nSelected publications\n\nM Kim\, M Panag iotakopoulou\, C Chen\, SB Ruiz\, K Ganesh\, T Tammela\, ...\, 2023. Micro -engineering and nano-engineering approaches to investigate tumour ecosyst ems. Nature Reviews Cancer\, 1-19\n\nSR Torborg\, Z Li\, JE Chan\, T Tamme la. 2022. Cellular and molecular mechanisms of plasticity in cancer. Trend s in Cancer 8 (9)\, 735-746\n\nMarjanovic ND\, Hofree M\, Chan JE\, … \, Rekhtman N\, Massion PP\, Poirier JT\, Mazutis L\, Li R\, Lee JH\, Amon A \, Rudin CM\, Jacks T\, Regev A\, Tammela T. (2020). Emergence of a High-P lasticity Cell State during Lung Cancer Evolution. Cancer Cell\, 38(2):229 -246\n\n \;\n\nGeneral information\n\n You can download and save all the autumn 2023 FoS-seminars to your calendar from here: https://seafile.u tu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participatio n list is circulated in the audience\n If you are a student and later wis h to get a certificate of attendance from the Frontier of Science seminars \, print out the seminar diary and after the seminar ask the BioCity coord inator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbid den.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/fos20 23autumn_400px-nelio-1.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20231029T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR