BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:359@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20240926T120000 DTEND;TZID=Europe/Helsinki:20240926T130000 DTSTAMP:20240916T131746Z URL:https://inflames.utu.fi/events/frontiers-of-science-james-c-costello/ SUMMARY:Frontiers of Science: James C. Costello DESCRIPTION:September 26th at 12:00\nOnsite event\nin Arje Scheinin auditor ium\, Dentalia\nAutumn 2024 program\n\nProf. James C. Costello\, Universit y of Colorado\, USA\nA novel mechanism of chemotherapy resistance by the r egulation of volume regulated anion channels\nHost: Teemu Daniel Laajala ( teelaa@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\ n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Costello after the seminar. This is a great possibility to learn hosting skills in friendly environment and cre ate connections for future. Everyone is welcome to join\, BioCity Turku wi ll offer the lunch.\n\nIf you got interested\, please send an email to bio cityturku@bioscience.fi\n\n \;\n\nToday\, we have the ability to take a snapshot of the transcriptional activity of genes\, identify mutations\, and quantify the protein and metabolite content of cells.  All of these measurements can be made at a systems-wide level. These data present the p otential to greatly improve our ability to characterize and treat disease\ ; however\, the rate of data production is far outpacing our ability to an alyze\, interpret\, and ultimately build predictive tools in medicine.  C ostello lab takes a complementary dry and wet lab approach to close the ga p between raw data and biological understanding. Their dry lab research fo cuses on developing and implementing computational tools that distill this large pool of genome-scale data into actionable hypothesis. Costello wet lab research brings the computational modeling to the bench where the aim is to characterize the genomic components that contribute to drug mode of action in cancer biology.\n\n \;\n\nSelected publications\n\nHughes CJ \, Fields KM\, Danis EP\, Hsu JY\, Neelakantan D\, Vincent MY\, Gustafson AL\, Oliphant MJ\, Sreekanth V\, Zaberezhnyy V\, Costello JC\, Jedlicka P\ , Ford HL. 2023. SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene net work in Ewing Sarcoma. Nat Commun. 2023 14(1):4357. doi: 10.1038/s41467-02 3-39945-w.\n\nde Jong FC\, Laajala TD\, Hoedemaeker RF\, Jordan KR\, van d er Made ACJ\, Boevé ER\, van der Schoot DKE\, Nieuwkamer B\, Janssen EAM\ , Mahmoudi T\, Boormans JL\, Theodorescu D\, Costello JC\, Zuiverloon TCM. 2023. Non-muscle-invasive bladder cancer molecular subtypes predict diffe rential response to intravesical Bacillus Calmette-Guérin. Sci Transl Med . 15(697):eabn4118. doi: 10.1126/scitranslmed.abn4118.\n\nSun D\, Nguyen T M\, Allaway RJ\, Wang J\, Chung V\, Yu TV\, Mason M\, Dimitrovsky I\, Eric son L\, Li H\, Guan Y\, Israel A\, Olar A\, Pataki BA\, Stolovitzky G\, Gu inney J\, Gulko PS\, Frazier MB\, Chen JY\, Costello JC\, Bridges SL Jr\; RA2-DREAM Challenge Community. 2022. A Crowdsourcing Approach to Develop M achine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis. JAMA Netw Open. 25(8):e2227423. doi: 10.1001/jamanetworkopen.2 022.27423.\n\nTarca AL\, Pataki BÁ\, Romero R\, Sirota M\, Guan Y\, Kutum R\, Gomez-Lopez N\, Done B\, Bhatti G\, Yu T\, Andreoletti G\, Chaiworapo ngsa T\; DREAM Preterm Birth Prediction Challenge Consortium\; Hassan SS\, Hsu CD\, Aghaeepour N\, Stolovitzky G\, Csabai I\, Costello JC. 2021. Cro wdsourcing assessment of maternal blood multi-omics for predicting gestati onal age and preterm birth. Cell Rep Med. 2(6):100323. doi: 10.1016/j.xcrm .2021.100323.\n\nGreene CS\, Costello JC. 2020. Biologically Informed Neur al Networks Predict Drug Responses. Cancer Cell. 38(5):613-615. doi: 10.10 16/j.ccell.2020.10.014.\n\n \;\n\nGeneral information\n\n You can dow nload and save all the autumn 2024 FoS-seminars to your calendar from here : https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not ne eded\, participation list is circulated in the audience\n If you are a st udent and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar as k the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e 46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Autumn 2024 FoS image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image cre ated in the PyMOL Molecular Graphics System\, Version 2.5 Schrödinger\, L LC.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/coste llo-400.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR