BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:173@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20221117T120000 DTEND;TZID=Europe/Helsinki:20221117T130000 DTSTAMP:20230120T083412Z URL:https://inflames.utu.fi/events/frontiers-of-science-fos-prof-johanna-m yllyharju/ SUMMARY:CANCELLED Frontiers of Science (FoS): Prof. Johanna Myllyharju DESCRIPTION:\n\nCANCELLED\nNovember 17th at 12:00\non-site event\nPresident ti auditorium\, BioCity\nAutumn 2022 poster\n\nProf. Johanna Myllyharju\, University of Oulu\, Finland\nProlyl 4-hydroxylation – a druggable prote in modification with central roles in collagen synthesis and regulation of hypoxia response\nHost: Jyrki Heino (jyrki.heino@utu.fi)\n\nCoffee and sa ndwich served at 11:45\n\nWe hope to invite Prof. Myllyharju to Turku duri ng  spring 2023\n\n \;\n\nProfessor Johanna Myllyharju is an expert o n the key enzymes regulating hypoxia response and extracellular matrix syn thesis. Oxygen and extracellular matrix homeostases are vital for normal f unctioning of cells and tissues\, and disturbances in their balance are as sociated with many common diseases. Therefore\, detailed information on th ese enzymes is essential for understanding their molecular mechanisms and biological effects in detail. This has already paved the way towards pharm acologic interventions\, exemplified by a longterm industrial collaboratio n to develop enzyme inhibitors that activate the hypoxia response as thera peutic drugs\, the first one being approved for treatment of severe anemia of chronic kidney diseases in 2018.\n\n \;\n\nSelected publications\n \nOllonen T\, Kurkela M\, Laitakari A\, Sakko S\, Koivisto H\, Myllyharju J\, Tanila H\, Serpi R\, Koivunen P. 2022. Activation of the hypoxia respo nse protects mice from amyloid-β accumulation. Cell Mol Life Sci. 2022 Ju l 19\;79(8):432.\n\nElamaa H\, Kaakinen M\, Nätynki M\, Szabo Z\, Ronkain en VP\, Äijälä V\, Mäki JM\, Kerkelä R\, Myllyharju J\, Eklund L. 202 2. PHD2 deletion in endothelial or arterial smooth muscle cells reveals va scular cell type-specific responses in pulmonary hypertension and fibrosis . Angiogenesis. 2022 May\;25(2):259-274.\n\nCockman ME\, Lippl K\, Tian YM \, Pegg HB\, Figg WD Jnr\, Abboud MI\, Heilig R\, Fischer R\, Myllyharju J \, Schofield CJ\, Ratcliffe PJ. 2019 Lack of activity of recombinant HIF p rolyl hydroxylases (PHDs) on reported non-HIF substrates. Elife. 2019 Sep 10\;8:e46490\n\n \n\nGeneral information\n\n You can download all autumn 2022 FoS-seminars in your calendar from here: https://seafile.utu.fi/d/db 29925e6f0e4becb755/\n Registration is not needed for on-site seminars\n Participation list is circulated in the audience\n If you are a student a nd later wish to get a certificate of attendance from the Frontier of Scie nce seminars\, please print out this seminar diary and after the seminar a sk the BioCity coordinator to sign it\n Please note that any audio or vid eo recording of the seminars is strictly forbidden.\n ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/2022/ 09/myllyharju-400px.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20221030T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR