BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:171@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20221103T120000 DTEND;TZID=Europe/Helsinki:20221103T133000 DTSTAMP:20230120T083412Z URL:https://inflames.utu.fi/events/frontiers-of-science-fos-prof-gilles-va n-wezel-prof-jacques-neefjes/ SUMMARY:Frontiers of Science (FoS): Prof. Gilles van Wezel & Prof. Jacques Neefjes DESCRIPTION:\n\nNovember 3rd at 12:00\non-site event\nPresidentti auditoriu m\, BioCity\nAutumn 2022 poster\n\nProf. Gilles van Wezel\, Leiden Univers ity\, Netherlands\nEcology-inspired approaches towards antibiotic discover y in Actinobacteria\nProf. Jacques Neefjes\, Leiden University Medical Cen ter\, Netherlands\nDetoxifying anthracycline anti-cancer drugs for new tre atment options of relapsed cancer patients\nHost: Mikko Metsä-Ketelä (mi anme@utu.fi)\n\nCoffee and sandwich served at 11:45\n\n \;\n\nSix stud ents and early-career postdocs are welcome to have a lunch in restaurant M auno and discuss with Profs. van Wezel and Neefjes after the seminar. This is a great possibility to learn hosting skills in friendly environment an d create connections for future. Every student are welcome to join\, in sp ite of which research group they belong to. BioCity Turku will offer the l unch.\n\nIf you got interested\, please send an email to biocityturku@bios cience.fi\n\n \;\n\nIn this double feature of the FoS seminar series\, our two speakers present how bioactive natural products can be discovered from microbes and developed into clinical drugs.\n\nThe lab of Gilles van Wezel primarily focuses on the actinomycetes\, which are multicellular my celial bacteria that produce two-third of all known antibiotics and many o ther molecules with medical application. Recent years have seen a resurgen ce of drug discovery efforts from microbial sources through state-of-the-a rt metabolomics\, genomics\, chemical ecology\, modelling approaches and a dvanced imaging technologies. Ground-breaking discoveries include the deve lopment of elicitors that activate antibiotic production and the discovery of the lugdunomycins\, a novel class of polyketides with unprecedented ch emical scaffold. The research of van Wezel is characterized by the strong resonance between fundamental and applied research\, and much of his resea rch is supported by public-private partnerships.\n\nResearch by Neefjes an d his laboratory has centered around several major themes including antige n presentation\, bacterial infections and cancer. Relevant for this talk i s development of anthracyclines for anticancer chemotherapy. Doxorubicin i s a widely used and highly effective anticancer drug\, but induces cardiot oxicity that prevents treatment of recurring tumours. When testing chemica l modulations of MHC antigen presentation\, Neefjes explored one of the mo st used frequently used classes of anti-cancer drugs—the anthracyclines —which were long thought to act by generating DNA double stranded breaks . In a breakthrough study\, Neefjes showed that some anthracyclines\, can also generate chromatin damage by ejecting histones from DNA and that the combination of these two activities is the cause of cardiotoxicity. In his recent work he has shown that this allows the development of cardiotoxici ty-free anthracyclines for clinical use.\n\n \;\n\nSelected publicatio ns\n\nAnthracyclines: biosynthesis\, engineering and clinical applications (2022) Mandy B Hulst\, Thadee Grocholski\, Jacques JC Neefjes\, Gilles P van Wezel\, Mikko Metsä-Ketelä\, Natural Product Reports\n\nEcology and genomics of Actinobacteria: new concepts for natural product discovery (20 20) Doris van Bergeijk\, Barbara Terlouw\, Marnix Medema\, Gilles van Weze l\, Nature Reviews Microbiology\, 18\, 546–558\n\nOmics-based strategies to discover novel classes of RiPP natural products (2021) Alexander M. Kl oosterman\, Marnix H. Medema\, Gilles P. van Wezel\, Current Opinion in Bi otechnology 69\, 60–67\n\nUncoupling DNA damage from chromatin damage to detoxify doxorubicin (2020) Xiaohang Qiao\, et al\, Proceedings of the Na tional Academy of Sciences 117\, 15182-15192\n\nDrug-induced histone evict ion from open chromatin contributes to the chemotherapeutic effects of dox orubicin (2013) Pang et al\, Nature Communications 4\, 1908\n\nChemical pr ofiling of the genome with anti-cancer drugs defines target specificities (2015) Pang et al\, Nature Chemical Biology\, 11\, pages 472–480\n\n&nbs p\;\n\nGeneral information\n\n You can download all autumn 2022 FoS-semin ars as .ics in your calendar from here: https://seafile.utu.fi/d/db29925e6 f0e4becb755/\n Registration is not needed for on-site seminars\n Partici pation list is circulated in the audience\n If you are a student and late r wish to get a certificate of attendance from the Frontier of Science sem inars\, please print out this seminar diary and after the seminar ask the BioCity coordinator to sign it\n Please note that any audio or video reco rding of the seminars is strictly forbidden.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/2022/ 09/wezel-neefjes-400px.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20221030T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR