BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:362@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20241205T120000 DTEND;TZID=Europe/Helsinki:20241205T130000 DTSTAMP:20240916T131932Z URL:https://inflames.utu.fi/events/frontiers-of-science-bernhard-kuster/ SUMMARY:Frontiers of Science: Bernhard Küster DESCRIPTION:December 5th at 12:00\nOnsite event\nin Presidentti auditorium\ , BioCity\nAutumn 2024 program\n\nProf. Bernhard Küster\, Technical Unive rsity of Munich\, Germany\nCancer patient and drug proteome profiling enha nce treatment recommendations in molecular tumor boards\nHost: Otto Kauko (otto.kauko@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first ser ved!\n\n \;\n\nSix PhD researchers and early-career postdocs are welco me to have a lunch and discuss with Prof. Küster after the seminar. This is a great possibility to learn hosting skills in a friendly environment a nd create connections for future. Everyone is welcome to join\, BioCity Tu rku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nProf. Küster leads Proteomics and Bioanalytics group at the Technical University of Munich\, which comp rises an international research team with a focus on proteomics and chemic al biology. Most of their research builds on the powerful combination of c ell biology\, chemistry\, biochemistry\, mass spectrometry and bioinformat ics. The group develops novel analytical methods for quantitative proteome research notably for high throughput applications and the analysis of pos t translational protein modifications (PTMs). In their chemical biology ef forts\, they elucidate the selectivity of drug-target interactions on a pr oteome-wide scale\, investigate the cellular mechanisms by which drugs exe rt their function and identify mechanisms of cancer therapy resistance. In addition\, the group investigates phosphoproteomic signaling events as bi omarkers for patient stratification\, as well as indicators of drug effect iveness and treatment response.\n\n \;\n\nSelected publications\n\nCha ng YC\, Gnann C\, Steimbach RR\, Bayer FP\, Lechner S\, Sakhteman A\, Abel e M\, Zecha J\, Trendel J\, The M\, Lundberg E\, Miller AK\, Kuster B. 202 4. Decrypting lysine deacetylase inhibitor action and protein modification s by dose-resolved proteomics. Cell Rep. 43(6):114272. doi: 10.1016/j.celr ep.2024.114272\n\nEckert S\, Berner N\, Kramer K\, Schneider A\, Müller J \, Lechner S\, Brajkovic S\, Sakhteman A\, Graetz C\, Fackler J\, Dudek M\ , Pfaffl MW\, Knolle P\, Wilhelm S\, Kuster B. 2024. Decrypting the molecu lar basis of cellular drug phenotypes by dose-resolved expression proteomi cs. Nat Biotechnol. doi: 10.1038/s41587-024-02218-y\n\nReinecke M\, Brear P\, Vornholz L\, Berger BT\, Seefried F\, Wilhelm S\, Samaras P\, Gyenis L \, Litchfield DW\, Médard G\, Müller S\, Ruland J\, Hyvönen M\, Wilhelm M\, Kuster B. 2024. Chemical proteomics reveals the target landscape of 1 \,000 kinase inhibitors. Nat Chem Biol. 20(5):577-585. doi: 10.1038/s41589 -023-01459-3.\n\nLechner S\, Steimbach RR\, Wang L\, Deline ML\, Chang YC\ , Fromme T\, Klingenspor M\, Matthias P\, Miller AK\, Médard G\, Kuster B . 2026. Chemoproteomic target deconvolution reveals Histone Deacetylases a s targets of (R)-lipoic acid. Nat Commun. 14(1):3548. doi: 10.1038/s41467- 023-39151-8.\n\n \;\n\nGeneral information\n\n You can download and s ave all the autumn 2024 FoS-seminars to your calendar from here: https://s eafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, part icipation list is circulated in the audience\n If you are a student and l ater wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar ask the BioCi ty coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictl y forbidden.\n Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyM OL Molecular Graphics System\, Version 2.5 Schrödinger\, LLC.\n\n \;\ n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/kuste r-400.jpg CATEGORIES:Events in English,Tapahtumat END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20241027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR