BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:314@inflames.utu.fi DTSTART;TZID=Europe/Helsinki:20240307T120000 DTEND;TZID=Europe/Helsinki:20240307T130000 DTSTAMP:20231220T091256Z URL:https://inflames.utu.fi/events/frontiers-of-science-assoc-prof-sirio-d upont/ SUMMARY:Frontiers of Science: Assoc. Prof. Sirio Dupont DESCRIPTION:\n\nMarch 7th at 12:00\nOn-site event\nPresidentti auditorium\, BioCity\nSpring 2024 program\n\nAssoc. Prof. Sirio Dupont\, University of Padova\, Italy\nMitochondrial fission coordinates the transcriptional and metabolic response to forces\nHost: Johanna Ivaska (johanna.ivaska@utu.fi )\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\ nSix PhD researchers and early-career postdocs are welcome to have a lunch in restaurant Mauno and discuss with Assoc. Prof. Dupont after the semina r. This is a great possibility to learn hosting skills in friendly environ ment and create connections for future. Everyone is welcome to join\, BioC ity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nDupont lab is interested in understanding how the mechanical properties of the extracellular matri x (ECM) regulate signaling pathways\, gene transcription and other cellula r processes\, and how this is relevant for cell behavior\, tissue homeosta sis and disease. Their goal is to identify novel general principles in vit ro\, and to push their validation in vivo with the development of new anim al models to study mechano-signaling in tissues. Dupont lab uses a multidi sciplinary approach that includes custom-built compliant cell culture subs trata\, ECM micropatterning\, cell micromanipulations\, optical microscopy \, molecular and cell biology techniques\, transcriptional and bioinformat ic analyses\, proteomics\, metabolomics\, CRISPR/Cas9 modified cell lines\ , and genetically-modified mice\, also thanks to multiple collaborations w ith colleagues in Italy and abroad. Dupont lab has identified YAP/TAZ tran scriptional coactivators as readers of ECM mechanical cues and mediators o f their effects on cancer cell proliferation and mesenchymal stem cell dif ferentiation\, and are now developing genetic tools to study the relevance of F-actin remodeling as regulator of YAP/TAZ activity in vivo. Moreover\ , they got recently interested in understanding how mechanical cues\, YAP/ TAZ and metabolism are reciprocally regulated.\n\n \;\n\nSelected publ ications\n\nDupont S\, Wickström SA. 2022. Mechanical regulation of chrom atin and transcription. Nat Rev Genet. 2022 Oct\;23(10):624-643. doi: 10.1 038/s41576-022-00493-6\n\nRomani P\, Nirchio N\, Arboit M\, Barbieri V\, T osi A\, Michielin F\, Shibuya S\, Benoist T\, Wu D\, Hindmarch CCT\, Giomo M\, Urciuolo A\, Giamogante F\, Roveri A\, Chakravarty P\, Montagner M\, Calì T\, Elvassore N\, Archer SL\, De Coppi P\, Rosato A\, Martello G\, D upont S. 2022. Mitochondrial fission links ECM mechanotransduction to meta bolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell B iol. 2022 Feb\;24(2):168-180. doi: 10.1038/s41556-022-00843-wPMID: 3516541 8\n\nRomani P\, Brian I\, Santinon G\, Pocaterra A\, Audano M\, Pedretti S \, Mathieu S\, Forcato M\, Bicciato S\, Manneville JB\, Mitro N\, Dupont S . 2019. Extracellular matrix mechanical cues regulate lipid metabolism thr ough Lipin-1 and SREBP. Nat Cell Biol. 2019 Mar\;21(3):338-347. doi: 10.10 38/s41556-018-0270-5\n\n \;\n\nGeneral information\n\n You can downlo ad and save all the spring 2024 FoS-seminars to your calendar from here: h ttps://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not neede d\, participation list is circulated in the audience\n If you are a stude nt and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar ask t he BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a 9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2024 FoS image credits to Jenny Pessa: Tran sformed human breast epithelial HS578T cells (flattened)\, labelled with c ommercial fluorescent antibodies. Image acquired on 3i CSU-W1 Spinning dis k with 40x objective.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://inflames.utu.fi/wp-content/uploads/dupon t-400.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20231029T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR